中华中医药杂志2026，Vol.41Issue(3)：912-917,6.
宫颈癌放射性直肠炎中医证候分布规律及影响因素分析
Analysis on the distribution pattern of traditional Chinese medicine symptoms and influencing factors of radiation proctitis in cervical cancer
摘要
Abstract
Objective:To analyze the distribution pattern and characteristics of traditional Chinese medicine(TCM)syndromes in cervical cancer-related radiation proctitis(RP),and to explore the correlation between its influencing factors and syndrome distribution.Methods:A total of 424 patients with cervical cancer-related RP admitted to the Department of Oncology,Shanxi Academy of Traditional Chinese Medicine from January 2020 to December 2023 were enrolled.Personal data,TCM syndrome information,and previous treatment history were collected and analyzed.Results:The main clinical manifestations of the 424 patients with cervical cancer-related RP included tenesmus,hematochezia,anal pain,diarrhea,abdominal pain,and mucosanguineous stools.The distribution of TCM syndromes in descending order of frequency was:syndrome of toxin damaging the collateral vessels due to heat,syndrome of yin deficiency and fluid depletion,syndrome of intermingled heat and cold,syndrome of spleen deficiency and dampness obstruction,and syndrome of spleen-kidney yang deficiency.Significant differences were observed in the distribution of TCM syndromes across subgroups of clinical stage,tumor size,radiotherapy duration,RTOG/EORTC grade,mean radiation dose,RP stage,pelvic inflammation,and intestinal polyps(P＜0.01,P＜0.05).Logistic regression analysis indicated that clinical stage Ⅲ-Ⅳ was positively correlated with syndrome of yin deficiency and fluid depletion and syndrome of spleen-kidney yang deficiency;tumor size＞4 cm,radiotherapy duration＞6 weeks,mean radiation dose＞60 Gy,and pelvic inflammation were positively correlated with syndrome of toxin damaging the collateral vessels due to heat and syndrome of yin deficiency and fluid depletion;the occurrence of syndrome of toxin damaging the collateral vessels due to heat was negatively correlated with RTOG/EORTC grade but positively correlated with syndrome of yin deficiency and fluid depletion;the occurrence of syndrome of yin deficiency and fluid depletion and syndrome of spleen-kidney yang deficiency was negatively correlated with RP stage;and intestinal polyps were positively correlated with syndrome of intermingled heat and cold.Conclusion:The most common TCM syndrome type in patients with cervical cancer-related RP is syndrome of toxin damaging the collateral vessels due to heat.Clinical stage,tumor size,radiotherapy duration,RTOG/EORTC grade,mean radiation dose,RP stage,pelvic inflammation,and intestinal polyps are all influencing factors for TCM syndromes.关键词
宫颈癌/放射性直肠炎/中医证候/影响因素Key words
Cervical cancer/Radiation proctitis(RP)/Traditional Chinese medicine syndrome/Influencing factors引用本文复制引用
石智尧,刘佳佳,孙祎濛,杨晓昆,高宇,王晞星..宫颈癌放射性直肠炎中医证候分布规律及影响因素分析[J].中华中医药杂志,2026,41(3):912-917,6.基金项目
第四届国医大师传承工作室(No.国中医药办人教函[2022]245号1123-04),国家中医药传承创新中心建设项目(No.202203),山西省自然科学基金基础面上项目(No.202103021224437),山西省中医临床医学研究中心(培育)(No.晋科社发[2019]61号),山西省卫生健康委员会山西省医学科技创新团队项目(No.2020TD04),山西省卫生健康委员会山西省医学重大科技攻关专项(No.2022XM10) （No.国中医药办人教函[2022]245号1123-04）
