中华中医药杂志2026，Vol.41Issue(3)：937-942,6.
基于杏仁核-海马探讨羽调音乐对恐惧记忆消退的作用机制
Exploration on the mechanism of Yu tune music on fear memory extinction based on the amygdala-hippocampus
摘要
Abstract
Objective:To investigate the mechanism of Yu tune music on fear memory extinction of conditioned fear mouse.Methods:Twenty-eight C57BL6/J male mice were randomly divided into control group,fear group,exposed group,and music group,7 in each group.A conditional fear model of mice was established using Pavlov conditioned reflex paradigm.The fear and anxiety states of mice were detected through fear conditioning test(FCT),elevated plus maze test(EPM),and Open field test(OFT),respectively.The excitability and functional connectivity of mouse brain neurons were observed through rs fMRI.Results:In terms of behavior,compared with the control group,freezing time(FT)value and FT percentage in FCT were significantly increased in the fear group(P＜0.01),while ot value in EPM and CWT value in OFT were significantly decreased(P＜0.01);Compared with the fear group,the FT value and FT percentage of mice in the music group and the exposed group were significantly lower on the 14th and 21st day of intervention(P＜0.01),the exposed group was better than the music group(P＜0.01),the OT and CWT values of the two groups were significantly higher(P＜0.01),and the music group was better than the exposed group(P＜0.01).The results of fMRI analysis of mice brain showed that ALFF in bilateral amygdala,hippocampus,visual cortex,prefrontal cortex,somatosensory cortex and other regions of mice in fear group increased significantly(P＜0.01);The ALFF of bilateral amygdala,hippocampus,prefrontal cortex and striatum in music group was significantly decreased(P＜0.01);ALFF in the left hypothalamus,amygdala,thalamus and other regions of the mice in the exposed group increased significantly(P＜0.01),while Alff in the right part of the hippocampus decreased significantly(P＜0.01).Functional connectivity analysis showed that compared with the control group,the functional connectivity between amygdala and hippocampus in the fear group was significantly increased(P＜0.01);The functional connection between amygdala and hippocampus in music group was significantly decreased(P＜0.01);The functional connection between somatosensory cortex and amygdala was weakened in the exposed group(P＜0.01).Conclusion:Yu tune music significantly facilitates the extinction of fear memories,with its mechanism may be related to modulating neural circuits in the brain associated with fear emotions.关键词
五音疗疾/羽调音乐/恐惧记忆/静息态功能性磁共振成像/惊恐伤肾/五行音乐/情志Key words
Five tone therapy for illness/Feather tune music/Fear memory/Resting state functional magnetic resonance imaging/Fear can damage the kidneys/Five element music/Emotion引用本文复制引用
丹禹钦,吴雨静,于功昌,李丽,聂彬彬,张龙元,冯梓芸,孙鹏伟,张梦圆,丁懿,许铛瀚,苏佳宁..基于杏仁核-海马探讨羽调音乐对恐惧记忆消退的作用机制[J].中华中医药杂志,2026,41(3):937-942,6.基金项目
国家自然科学基金面上项目(No.82374556),国家重点研发计划中医药现代化研究重点专项课题(No.2018YFC1706005),山东省中医药科技发展计划面上项目(No.2021M006) （No.82374556）
