中国中医药信息杂志2026，Vol.33Issue(5)：110-116,7.DOI:10.19879/j.cnki.1005-5304.202508382
痰火方对急性缺血性卒中痰热证患者舌苔菌群的影响
Effects of Tanhuo Prescription on Tongue Coating Microbiota in Patients with Phlegm-heat Syndrome of Acute Ischemic Stroke
摘要
Abstract
Objective To explore the clinical efficacy of Tanhuo Prescription in patients with phlegm-heat syndrome of acute ischemic stroke(AIS)and its regulatory effect on tongue coating microbiota.Methods Totally 112 AIS patients with phlegm-heat syndrome were divided into the treatment group and the control group(56 cases per group)by means of random number table method.Both groups were treated with conventional antiplatelet therapy,lipid-lowering and plaque stabilization therapy.In addition to this conventional therapy,the treatment group received the modified Tanhuo Prescription orally.The treatment course was 10-14 days for both groups.The following outcomes were compared between the two group:clinical efficacy rate,National Institute of Health stroke scale(NIHSS)score,modified Rankin Scale(mRS)score,TCM syndrome score,activities of daily living(ADL)score,and changes in tongue coating microbiota.Results There were 3 dropouts in the treatment group and 1 dropout in the control group.The total clinical efficacy rate was 92.5%(49/53)in the treatment group and 72.7%(40/55)in the control group,and the efficacy of treatment group was superior to that of the control group(P<0.05).Compared with before treatment,the NIHSS score,ADL score and TCM syndrome score in the treatment group were significantly improved after treatment(P<0.05).There was no statistical difference in mRS score between before and after treatment in the treatment group(P>0.05);in the control group,the NIHSS score and the TCM syndrome score were significantly improved after treatment(P<0.05),while mRS score and ADL score showed no statistically significant differences(P>0.05).After treatment,the improvement of NIHSS score,ADL score,TCM syndrome score in the treatment group was better than that in the control group(P<0.05),and there was no significant difference in mRS score between the two groups(P>0.05).After treatment,the relative abundance of Granulicatella and Parvimonas in the treatment group was lower than that in the control group,while the relative abundance of Megasphaera was higher than that in the control group(P<0.05).After treatment,the recovery of anhydrous peptidoglycan,the degradation of galactose and the degradation of N-acetylglucosamine,N-acetylmannosamine and N-acetylneuraminic acid in the treatment group were lower than those in the control group,and the synthesis of arginine was higher than that in the control group(P<0.05).Conclusion Tanhuo Prescription has good clinical efficacy in patients of AIS with phlegm-heat syndrome.It has a good improvement effect on patients'neurological deficits,and the mechanism may be related to the modulation of the abundance of tongue coating microbiota and their metabolic pathways.关键词
急性缺血性卒中/痰热证/舌苔菌群/痰火方Key words
acute ischemic stroke/phlegm-heat syndrome/tongue coating microbiota/Tanhuo Prescription分类
医药卫生引用本文复制引用
龙金瑶,高利,王宁群..痰火方对急性缺血性卒中痰热证患者舌苔菌群的影响[J].中国中医药信息杂志,2026,33(5):110-116,7.基金项目
首都卫生发展科研专项(首发2022-2-2018) （首发2022-2-2018）
