中国针灸2026，Vol.46Issue(5)：725-731,7.DOI:10.13703/j.0255-2930.20250915-k0003
电针联合西药治疗非糜烂性反流病:随机对照试验
Electroacupuncture combined with western medication for non-erosive reflux disease:a randomized controlled trial
摘要
Abstract
Objective To compare the clinical efficacy on non-erosive reflux disease(NERD)among electroacupuncture(EA)combined with rabeprazole sodium enteric-coated capsules,sham-EA combined with rabeprazole sodium enteric-coated capsules,and rabeprazole sodium enteric-coated capsules alone.Methods A total of 156 patients with NERD were randomly assigned,at 1∶1∶1,into an EA group(52 cases,2 cases dropped out),a sham-EA group(52 cases,2 cases dropped out),and a western medication group(52 cases,2 cases dropped out).In the western medication group,rabeprazole sodium enteric-coated capsules were administered orally,20 mg,once daily and for 8 weeks.In the EA group,besides the medication as the western medication group,EA was operated at the positive reaction points along the governor vessel,Dazhui(GV14)and Baihui(GV20),etc.,with continuous wave and at the frequency of 10 Hz and an electric intensity of 2-5 mA.EA was delivered once every 2 days,3 sessions a week and for 8 weeks.In the sham-EA group,the stimulating point selection and EA operation were the same as the EA group,but without electric stimulation exerted.The scores of reflux disease questionnaire(RDQ),self-rating anxiety scale(SAS),and self-rating depression scale(SDS)were assessed before and after treatment,as well as in the 3-month follow-up;and the clinical efficacy was evaluated in each group.Results After treatment and in the 3-month follow-up,the scores of RDQ and SDS were reduced in each group(P＜0.05);the EA group showed the lower scores of RDQ and SDS when compared with those in the sham-EA group and the western medication group(P＜0.05),and the scores of RDQ and SDS in the sham-EA group were lower than those of the western medication group(P＜0.05).The SAS score was lower after treatment in comparison with that before treatment in each group(P＜0.05),and the score in both the EA group and the sham-EA group was reduced in follow-up(P＜0.05).After treatment and in follow-up,SAS scores in the EA group were lower than those in the sham-EA group and the western medication group,respectively(P＜0.05),and the scores in the sham-EA group were lower when compared with those in the western medication group(P＜0.05).The total effective rate in the EA group was 96.0%(48/50),higher than that in the sham-EA group(92.0%,46/50)and the western medication group(86.0%,43/50,P＜0.05);and the total effective rate in the sham-EA group was higher than that in the western medication group(P＜0.05).Conclusion Electroacupuncture combined with rabeprazole sodium enteric-coated capsules effectively alleviates clinical symptoms and emotional disorders in patients with NERD,presenting sustained therapeutic effect;and its efficacy is superior to the combined regimen of sham-EA and rabeprazole sodium enteric-coated capsules or the administration with rabeprazole sodium enteric-coated capsules alone.关键词
非糜烂性反流病/电针/假电针/雷贝拉唑/随机对照试验Key words
non-erosive reflux disease/electroacupuncture/sham-electroacupuncture/rabeprazole/randomized controlled trial(RCT)引用本文复制引用
顾茜彦,张建斌,陈贵生,施大中,冯雨露,马艺桐,陈朝明,卢文,夏筱方,周志..电针联合西药治疗非糜烂性反流病:随机对照试验[J].中国针灸,2026,46(5):725-731,7.基金项目
江苏省中医药科技发展计划项目:YB2020028 （）
南京市卫生科技发展项目:ZKX24044 （）
第六批南京市老中医药专家学术经验继承项目:2024NJLPSC （）
江苏省研究生实践创新计划项目:SJCX25_1038 （）
