中国中医药信息杂志2026，Vol.33Issue(5)：153-159,7.DOI:10.19879/j.cnki.1005-5304.202509137
中医药调控TGF-β及相关信号通路干预早发性卵巢功能不全研究进展
Research Progress in TCM Regulation of TGF-β and Related Signaling Pathways for Intervening Premature Ovarian Insufficiency
摘要
Abstract
Premature ovarian insufficiency(POI)is a common and complex gynecological disorder that significantly impacts patients'physical and mental health.Abnormal activation of transforming growth factor-β(TGF-β)and its signaling pathways can influence pathological processes such as inflammatory responses,oxidative stress,autophagy,and apoptosis,thereby accelerating POI progression.This article reviewed the research progress of TCM regulating TGF-β and related signaling pathways in the treatment of POI from the aspects of Chinese materia medica monomer,compound prescriptions and combination therapy.Research confirms that Chinese materia medica monomers,such as luteolin,poplarin,icariin,and curcumin,as well as TCM prescription,such as Zuogui Pills,modified Yijing Decoction,and Butian Dazao Pills,and the combination of Chinese materia medica with acupuncture,could regulate TGF-β and its associated signaling pathways.These interventions could improve the ovarian tissue microenvironment,alleviate ovarian function decline,and enhance ovarian reserve capacity,which could provide references for TCM intervention in POI research and clinical application.关键词
早发性卵巢功能不全/转化生长因子-β相关信号通路/中医药/综述Key words
premature ovarian insufficiency/TGF-β-related signaling pathways/traditional Chinese medicine/review分类
医药卫生引用本文复制引用
陈琳,李昕蓉,李冰霞,武权生,杨文文,岳斌,陈元欢,王颐轩,张小花,王玮,罗紫婷..中医药调控TGF-β及相关信号通路干预早发性卵巢功能不全研究进展[J].中国中医药信息杂志,2026,33(5):153-159,7.基金项目
国家自然科学基金(82260949、82560954) （82260949、82560954）
甘肃省中医药科研课题(GZKP-2023-17) （GZKP-2023-17）
甘肃中医药大学人才引进项目(301/30140603) （301/30140603）
