中国中医药信息杂志2026，Vol.33Issue(5)：160-164,封3,6.DOI:10.19879/j.cnki.1005-5304.202509022
人参及其活性成分干预骨质疏松症药理作用研究进展
Research Progress in the Pharmacological Mechanisms of Ginseng Radix et Rhizoma and Its Active Components in Intervening Osteoporosis
摘要
Abstract
Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and microarchitectural deterioration of bone tissue,posing a significant health challenge in the increasingly aging society.Ginseng Radix et Rhizoma,a traditional herb for replenishing qi,has the effects of tonifying primordial qi,restoring pulse and securing collapse,reinforcing the spleen and lung,generating fluid and nourishing blood,as well as calming the mind and boosting intelligence,with the potential to intervene osteoporosis.Ginsenosides and ginseng polysaccharides are the most abundant and extensively studied active components in Ginseng Radix et Rhizoma.This article reviewed the pharmacological effects of Ginseng Radix et Rhizoma and its active components on osteoporosis and revealed that Ginseng Radix et Rhizoma and its active components regulate bone metabolism by promoting osteoblast proliferation and differentiation,inhibiting osteoclast formation and activity,modulating intestine-bone axis,and exerting antioxidant stress effects,thereby contributing to the prevention and treatment of osteoporosis.At present,preclinical studies have revealed the molecular mechanism of Ginseng Radix et Rhizoma and its active components regulating bone metabolism,but high-quality clinical evidence is still lacking,which needs to be further verified by large sample randomized controlled clinical trials,so as to provide references for the comprehensive development and utilization of Ginseng Radix et Rhizoma.关键词
人参/骨质疏松症/人参皂苷/骨代谢/成骨细胞/破骨细胞/肠-骨轴/综述Key words
Ginseng Radix et Rhizoma/osteoporosis/ginsenosides/bone metabolism/osteoblasts/osteoclasts/gut-bone axis/review引用本文复制引用
曲英泽,于冬冬..人参及其活性成分干预骨质疏松症药理作用研究进展[J].中国中医药信息杂志,2026,33(5):160-164,封3,6.基金项目
国家自然科学基金面上项目(82374480) （82374480）
