中国中医眼科杂志2026，Vol.36Issue(5)：455-459,475,6.DOI:10.13444/j.cnki.zgzyykzz.2026.05.010
基于"脾主运化"理论探讨"脾-肠-眼"轴在湿性年龄相关性黄斑变性防治中的作用
Exploring the Role of Spleen-intestine-eye Axis in the Prevention and Treatment of Wet Age-related Macular Degeneration Based on the Theory of Spleen Governing Trans-portation and Transformation
摘要
Abstract
Wet age-related macular degeneration(wAMD)is one of the main causes of irreversible visual impairment in the elderly population.The pathological site is located in the retina.The factors such as aging,smoking,and environment all affect the occurrence of wAMD.The etiology and pathogenesis in Traditional Chinese Medicine(TCM)are mostly attributed to spleen failing to govern transportation and transformation.Dysfunction of spleen governing transportation and transformation leads to dampness and turbidity rising upward,stagnating in the eye,and obstructing the spirit light.Therefore,whether the spleen's function of governing transportation and transformation is normal greatly affects retinal function.Spleen and intestine are functionally interconnected and pathologically related.Gut microbiota,as an important material basis of spleen governing transportation and transformation,can interact with wAMD through metabolic products,inflammation,immune responses,and other pathways.Thus,this paper constructs the spleen-intestine-eye axis,aiming to integrate microbiome studies with the theory of spleen governing transportation and transformation through this axis,explore the mechanisms and preventive measures of wAMD in modern medicine,and provide a theoretical basis for optimizing integrated TCM and Western Medicine diagnostic and therapeutic strategies for wAMD.关键词
"脾-肠-眼"轴/湿性年龄相关性黄斑变性/肠道菌群/脾主运化/中西医结合Key words
spleen-intestine-eye axis/wet age-related macular degenera-tion/gut microbiota/spleen governing transportation and transformation/inte-gration of Traditional Chinese Medicine and Western Medicine分类
医药卫生引用本文复制引用
彭文玲,张佳仪,吴权龙,彭清华..基于"脾主运化"理论探讨"脾-肠-眼"轴在湿性年龄相关性黄斑变性防治中的作用[J].中国中医眼科杂志,2026,36(5):455-459,475,6.基金项目
1 国家重点研发计划项目(2024YFC3505400)2 湖南省自然科学基金创新研究群体项目(2024JJ1007) （2024YFC3505400）
