中国中医药图书情报杂志2026，Vol.50Issue(3)：6-11,17,7.DOI:10.3969/j.issn.2095-5707.202505125
基于网络药理学与分子对接探讨温胆汤"异病同治"失眠和抑郁症的作用机制
Exploration on the Mechanism of Wendan Decoction for"Treating Different Diseases with the Same Therapy"in Insomnia and Depression Based on Network Pharmacology and Molecular Docking
摘要
Abstract
Objective To explore the mechanism of Wendan Decoction for"treating different diseases with the same therapy"in the treatment of insomnia and depression using network pharmacology;To conduct verification through molecular docking.Methods The active components of Wendan Decoction were obtained through the TCMSP database and literature retrieval,and their action targets were predicted.The disease-related targets of insomnia and depression were retrieved in the GeneCards,OMIM and TTD databases,and the intersection with the action targets of the active components was taken.The STRING platform was used to construct the protein-protein interaction(PPI)network of the intersection targets,and NOC and Mcode were used to analyze the core targets.The Metascape platform was used to perform GO and KEGG pathway enrichment analysis on the intersection targets.Finally,AutoDock was used for molecular docking verification.Results Totally 60 active components and 321 targets of Wendan Decoction were screened.The core components in the formula included luteolin,quercetin,naringenin,β-carotene,baicalein,etc.The core intersection targets mainly included AKT1,IL6,TNF,IL1B,CYCS,etc.The KEGG pathway was mainly enriched in the pathways of IL-17,dopaminergic synapses,etc.The results of molecular docking showed that the binding activity between the core components and the core targets was good.Conclusion Wendan Decoction exerts the effect of"treating different diseases with the same therapy"in the treatment of insomnia and depression by inhibiting inflammatory reactions,promoting neuron repair and regulating neurotransmitters.关键词
温胆汤/失眠/抑郁症/网络药理学/分子对接/作用机制Key words
Wendan Decoction/insomnia/depression/network pharmacology/molecular docking/mechanism分类
医药卫生引用本文复制引用
张琰彬,张圣宏,李福伦..基于网络药理学与分子对接探讨温胆汤"异病同治"失眠和抑郁症的作用机制[J].中国中医药图书情报杂志,2026,50(3):6-11,17,7.基金项目
上海市卫生健康委员会中医药科研创新团队项目(2022CX011) （2022CX011）
上海市杨浦区卫健系统"好医师"项目(240213) （240213）
上海中医药大学附属龙华医院院级项目(YW.005.009) （YW.005.009）
