中国中医药图书情报杂志2026，Vol.50Issue(3)：41-46,6.DOI:10.3969/j.issn.2095-5707.202506136
基于隐结构模型和聚类分析的肺结节常见中医证候研究
Study on Common Syndromes of Pulmonary Nodules Based on Latent Structure Model Combined with Clustering Analysis
摘要
Abstract
Objective To explore the distribution of TCM syndromes of pulmonary nodules;To provide theoretical basis for standardized clinical diagnosis and treatment of pulmonary nodules.Methods This study collected general data and TCM for diagnostic information of 420 pulmonary nodules patients from Changzhou Affiliated Hospital of Nanjing University of Chinese Medicine.Factor analysis and clustering analysis were conducted using SPSS 27.0 software,while latent structure modeling was performed with the LTM-EAS algorithm in Lantern 5.0 software.Clinical summaries were combined with multivariate statistical analysis to identify common syndrome patterns of pulmonary nodules.Results A total of 175 TCM symptom items were collected.Among them,41 main symptom items with frequency>20 produced 17 common factors.The pathological locations of pulmonary nodules were primarily associated with lung,spleen and liver organs.Common pathogenic factors included deficiency,phlegm,dampness,qi,fire,stagnation and blood stasis.Combined with TCM knowledge,clustering analysis identified 8 potential TCM syndromes.Latent structure model analysis was performed on 96 symptom items with frequency≥3,and 17 latent variables were generated,yielding 9 potential syndromes through comprehensive clustering.Combined with clinical summary,7 common syndrome types and corresponding symptoms of pulmonary nodules were inferred.Conclusion Lung qi deficiency syndrome,lung spleen qi deficiency syndrome and qi yin deficiency syndrome are common in TCM deficiency syndromes of pulmonary nodules,while phlegm turbid obstructing lung syndrome,phlegm heat accumulating lung syndrome,phlegm and blood stasis internal stagnation syndrome and liver stagnation and qi stagnation syndrome are common in excess syndrome.This study uses multivariate statistical analysis method to explore the common TCM syndrome patterns of pulmonary nodules from different dimensions,and provides the basis for the standardization of TCM syndrome patterns of pulmonary nodules.关键词
肺结节/证候/隐结构模型分析/因子分析/聚类分析Key words
pulmonary nodules/common syndromes/latent structure model/factor analysis/clustering analysis分类
医药卫生引用本文复制引用
朱敏,庄鑫,沈春锋..基于隐结构模型和聚类分析的肺结节常见中医证候研究[J].中国中医药图书情报杂志,2026,50(3):41-46,6.基金项目
全国名老中医药专家传承工作室建设项目(2018年) （2018年）
常州市科技局社会发展科技支撑项目(CE20225053) （CE20225053）
常州市卫生健康青苗人才培养工程项目(CZQM2023018) （CZQM2023018）
