肿瘤综合治疗电子杂志2026，Vol.12Issue(1)：34-48,15.DOI:10.12151/JMCM.2026.01-05
化疗联合免疫治疗后行转化手术可改善无腹膜转移Ⅳ期胃癌患者的生存结局——双中心回顾性研究
Conversion surgery provides survival benefit for patients with stage Ⅳ gastric cancer without peritoneal metastasis following immunochemotherapy:a dual-center retrospective study
钱昊 1梁华元 2张嘉洸 1王林俊 3赵丽瑛 4陈晓锋5
作者信息
- 1. 南京医科大学第一附属医院 肿瘤科,江苏 南京 210029
- 2. 清华大学临床医学院 北京清华长庚医院 胃肠外科,北京 102218
- 3. 南京医科大学第一附属医院 胃肿瘤中心,江苏 南京 210029||南京医科大学第一附属医院 普通外科,江苏 南京 210029
- 4. 南方医科大学第一临床医学院 南方医科大学南方医院 普通外科 暨广东省胃肠肿瘤精准医学重点实验室,广东 广州 510515||南方医科大学南方医院 胃癌中心,广东 广州 510515
- 5. 南京医科大学第一附属医院 肿瘤科,江苏 南京 210029||南京医科大学第一附属医院 胃肿瘤中心,江苏 南京 210029||江苏省肿瘤分子标志物与个体化治疗重点实验室和个体化癌症医学协同创新中心 南京医科大学,江苏 南京 211166
- 折叠
摘要
Abstract
Objective To investigate whether conversion surgery(CS)can enhance clinical outcomes for patients with stage Ⅳ gastric cancer without peritoneal metastasis following immunochemotherapy.Method We retrospectively analyzed data from patients with stage Ⅳ gastric cancer who were initially treated with immunochemotherapy at the First Affiliated Hospital of Nanjing Medical University and the First Clinical Medical College of Southern Medical University from November 1,2019 to April 23,2024.Patients were classified into CS group and non-conversion surgery(NCS)group.A 1 vs.2 propensity score matching(PSM)was performed to balance baseline characteristics.The event-free survival(EFS)and overall survival(OS)were compared between the two groups,and multivariable Cox regression analyses were performed to identify independent prognostic factors associated with EFS and OS.Result Among 230 enrolled patients(CS group:68 cases;NCS group:162 cases)and 133 patients after matching(CS group:43 cases;NCS group:90 cases),median event-free survival(mEFS)and median overall survival(mOS)were not reached in the CS group,whereas the NCS group showed mEFS of 9.34 months(95%CI:8.75-10.79)and 10.79 months(95%CI:9.04-15.02)and mOS of 19.67 months(95%CI:17.06-23.14)and 20.43 months(95%CI:18.15-35.25),respectively.Survival analyses consistently favored the CS group,and multivariate Cox analysis confirmed CS as an independent predictor of improved survival.Conclusion This study found that radical CS following response to first-line immunochemotherapy may significantly improve clinical outcomes and survival in this patient population,further prospective randomized study is warranted.关键词
转化手术/化疗联合免疫治疗/Ⅳ期胃癌/倾向评分匹配/回顾性研究Key words
Conversion surgery/Immunochemotherapy/Stage Ⅳ gastric cancer/Propensity score matching/Retrospective cohort引用本文复制引用
钱昊,梁华元,张嘉洸,王林俊,赵丽瑛,陈晓锋..化疗联合免疫治疗后行转化手术可改善无腹膜转移Ⅳ期胃癌患者的生存结局——双中心回顾性研究[J].肿瘤综合治疗电子杂志,2026,12(1):34-48,15.
