中国药理学通报2026，Vol.42Issue(4)：601-606,6.DOI:10.12360/CPB202511003
铁死亡在肝脏代谢性疾病中的作用机制研究进展
Research progress on mechanism of ferroptosis in metabolic liver diseases
摘要
Abstract
Ferroptosis is an iron-dependent,lipid peroxidation-driven form of regulatory cell death that differs from apoptosis,necrotic apoptosis,pyroptosis,and copper-induced cell death in both biochemical mechanisms and cellular morphological characteristics.This review explores the intrinsic linkages be-tween iron homeostasis,lipid peroxidation,metabolic dysfunction-associated fatty liver disease(MASLD),and its po-tential progression to hepatocellular carcinoma(HCC),based on current research.Research indicates that iron metabolism imbalance—particularly ferroptosis—triggers lipid peroxidation and ferroptosis by generating reactive oxygen species(ROS)via the Fenton reaction.In MASLD,ferroptosis participates in the progression from simple steatosis to metabolic dysfunction-associated steatohepatitis(MASH)and liver fibrosis.In HCC,ferroptosis plays a complex dual role:it functions as an intrinsic tumor suppression mechanism eliminating malignant cells while enabling cancer cells to acquire ferroptosis resistance,thereby promoting tumor progression and inducing tolerance to targeted therapies.Understanding these mechanisms provides potential targets for developing novel therapeutic strategies against both MASLD and HCC.关键词
铁死亡/代谢功能障碍相关脂肪性肝病/肝细胞癌/脂质过氧化/氧化应激Key words
ferroptosis/metabolic dysfunction-associated fatty liver disease/hepatocellular carcinoma/lipid peroxidation/oxi-dative stress分类
医药卫生引用本文复制引用
王钰萱,赵永旭..铁死亡在肝脏代谢性疾病中的作用机制研究进展[J].中国药理学通报,2026,42(4):601-606,6.基金项目
国家自然科学基金面上项目(No 82070824) （No 82070824）
山东省重点研发计划(No 2024CXPT028) （No 2024CXPT028）
