中国药理学通报2026，Vol.42Issue(4)：606-610,5.DOI:10.12360/CPB202509109
缺氧诱导因子-1α及其在疾病中的变化研究进展
Research progress on hypoxia-inducible factor-1α and its changes in diseases
摘要
Abstract
Hypoxia-inducible factor-1α(HIF-1α)is a core tran-scription factor that enables cells to adapt to hypoxic environ-ments and it is involved in various processes such as angiogen-esis,energy metabolism,cell proliferation,and apoptosis.In recent years,numerous studies have revealed that abnormal el-evation of HIF-1α levels is closely related to the nervous sys-tem,respiratory system,cardiovascular system,and metabolic diseases,suggesting its significant role in the occurrence and development of hypoxia-related diseases.This article reviews the structural characteristics and regulatory mechanisms of HIF-1α,focuses on summarizing its expression changes and func-tions in various diseases,explores its potential as a diagnostic marker and therapeutic target,and looks forward to future re-search directions.关键词
缺氧诱导因子-1α/缺氧/常氧/疾病机制/信号通路/生物标志物Key words
hypoxia-inducible factor-1α/hypoxia/normoxia/disease mechanism/signaling pathway/biomarker分类
医药卫生引用本文复制引用
李丰珍,于莹,杨雯晴,程肖蕊..缺氧诱导因子-1α及其在疾病中的变化研究进展[J].中国药理学通报,2026,42(4):606-610,5.基金项目
国家自然科学基金面上项目(No 82374062) （No 82374062）
山东省技术创新引导计划(中央引导地方科技发展资金)(No YDZX2023137,YDZX2023003) （中央引导地方科技发展资金）
山东医药卫生科技(No 202503101085) （No 202503101085）
