中国药理学通报2026，Vol.42Issue(4)：623-628,6.DOI:10.12360/CPB202505025
GnT-V调控N-糖基化促进肿瘤恶性表型的研究进展
Advances in GnT-V-regulated N-glycosylation and its role in promoting malignant tumor phenotypes
摘要
Abstract
GnT-V/MGAT5(alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase),a key enzyme regulat-ing N-glycosylation,is responsible for synthesizing β1,6-GlcNAc-branched N-glycans by catalyzing the formation of β1,6-glycosidic linkages.It plays a significant role in modulating the malignant phenotypes of tumor cells.Although previous studies have demonstrated the involvement of GnT-V in tumor proliferation,cell adhesion,invasion,migration,and immune evasion,its detailed mechanisms of action within tumors have not been systematically reviewed and summarized.Conse-quently,this article comprehensively explores how GnT-V par-ticipates in regulating malignant progression in tumor cells,ana-lyzes its pivotal role in tumor glycobiology,and discusses its po-tential clinical applications.This review aims to provide a theo-retical foundation for developing GnT-V-targeted anti-tumor therapeutics.关键词
N-乙酰氨基葡萄糖转移酶V/N-糖基化/肿瘤/增殖/黏附/侵袭/迁移/免疫逃逸Key words
N-acetylglucosaminyltransferase V/N-glycosyl-ation/tumor/proliferation/adhesion/invasion/metastasis/immune escape分类
医药卫生引用本文复制引用
韦昕瑀,韦惠兰,黄吉富,蒋木紫,韦姗姗,罗卓,阳洁..GnT-V调控N-糖基化促进肿瘤恶性表型的研究进展[J].中国药理学通报,2026,42(4):623-628,6.基金项目
国家自然科学基金资助项目(No 8237142603) （No 8237142603）
广西自然科学基金项目重点项目(No 2023GXNSFDA026026) （No 2023GXNSFDA026026）
广西自然科学基金杰出青年项目(No 2025GXNSFFA069017) （No 2025GXNSFFA069017）
