中国药理学通报2026，Vol.42Issue(4)：629-634,6.DOI:10.12360/CPB202508102
STING抑制剂在脑卒中后炎症反应中的调控作用与研究进展
The regulatory role and research advances of STING inhibitors in post-stroke inflammation
摘要
Abstract
Stroke is an acute neurological injury caused by a sudden interruption of cerebral blood supply,which imposes a heavy burden on patients due to its high mortality and disability rates.Following a stroke,the cGAS-STING pathway becomes activated,strongly inducing a type Ⅰ interferon response that ex-acerbates stroke-related damage.Targeted inhibition or degra-dation of STING can alleviate excessive inflammatory signaling and improve therapeutic outcomes.Strategies for STING inhibi-tion include the use of covalent inhibitors and competitive an-tagonists that target the ligand-binding domain(LBD)to block cyclic dinucleotide(CDN)binding,thereby suppressing STING activation.In addition,selective degradation of STING via the ubiquitin-proteasome system has also demonstrated promising efficacy.This review examines the role of the cGAS-STING pathway in stroke and summarizes recent advances in the development of STING inhibitors and degraders for the treat-ment of stroke.We aim to provide new perspectives and strate-gies to support the development of innovative anti-stroke thera-pies targeting STING.关键词
脑卒中/cGAS-STING通路/STING抑制剂/STING降解剂/神经炎症/药物治疗Key words
stroke/cGAS-STING pathway/STING inhibitors/STING degraders/neuroinflammation/pharmacological therapy分类
医药卫生引用本文复制引用
张雪婷,黄文鹏,胡凯超,楚世峰,陈乃宏..STING抑制剂在脑卒中后炎症反应中的调控作用与研究进展[J].中国药理学通报,2026,42(4):629-634,6.基金项目
国家自然科学基金资助项目(No U2202214) （No U2202214）
