中国药理学通报2026，Vol.42Issue(4)：651-659,9.DOI:10.12360/CPB202508071
环状多肽OCP 2对高原缺氧小鼠脑组织保护作用
The protective effect of cyclic peptide OCP 2 on brain tissue in high-altitude hypoxic mice
摘要
Abstract
Aim To clarify the anti-high-altitude hy-poxia activity of OCP 2 and its protective effect on brain tissue of high-altitude hypoxia mice.Method The survival time of mice under atmospheric pressure and hypoxia at different dosing intervals and doses were observed.Sixty mice were randomly divided into a blank control group,an hypoxia model group,an ac-etazolamide group,and OCP 2 low-,medium-,and high-dose groups,with 10 mice in each group.The blank control group was placed in a barrier environ-ment,while the remaining groups were placed at a simulated altitude of 8000 m.After 24 hours,patho-logical analysis of brain tissue was performed to deter-mine hypoxia related indicators.Results The optimal dosing interval was 10 minutes,and OCP 2(5-100 mg·kg-1)significantly improved the survival time of mice under atmospheric pressure and hypoxia.Com-pared with the blank control group,the pathological score of the hypoxia model group significantly in-creased.The levels of catalase(CAT),superoxide dismutase(SOD),and glutathione(GSH)were sig-nificantly reduced,and the expression levels of peroxi-some proliferators activated receptors-γ(PPAR γ)and its co activator 1 alpha(PGC1 α)were significantly re-duced.The levels of inflammatory factors such as in-terleukin-6(IL-6),malondialdehyde(MDA),and hy-poxia inducible factor 1 alpha(HIF-1 alpha)signifi-cantly increased.Compared with the hypoxia model group,the pathological scores of each OCP2 group sig-nificantly decreased.The levels of SOD,CAT,and GSH,as well as the expression levels of PGC-1 α and PPAR γ,significantly increased,while the levels of in-flammatory factors such as IL-6,MDA,and HIF-1 α expression significantly decreased.Conclusion OCP 2 has a good protective effect on brain injury in mice with high altitude hypoxia,which may be related to im-proving antioxidant capacity,inhibiting inflammatory factors and HIF-1α/PGC1α/PPARγ pathway.关键词
OCP 2/高原缺氧/脑损伤/氧化应激/炎症反应/HIF-1α/PGC1α/PPARγ信号通路Key words
OCP 2/high altitudes hypoxia/brain in-jury/oxidative stress/inflammatory response/HIF-1α/PGC1α/PPARγ signaling pathway分类
医药卫生引用本文复制引用
魏旭,张佩,章自会,魏振龙,高玉海,赵映申,冷非凡,申栋帅,陈克明..环状多肽OCP 2对高原缺氧小鼠脑组织保护作用[J].中国药理学通报,2026,42(4):651-659,9.基金项目
甘肃省科技重大专项(No 24ZDFA008) （No 24ZDFA008）
甘肃省自然科学基金资助项目(No 22JR5RA1052,24JRRA010,25JRRA432) （No 22JR5RA1052,24JRRA010,25JRRA432）
