中国生物防治学报2026，Vol.42Issue(2)：305-316,12.DOI:10.16409/j.cnki.2095-039x.2026.05.004
昆虫气味受体结构解析、机制探究与应用进展
Advances in the Structural Elucidation,Mechanistic Understanding,and Applications of Insect Odorant Receptors
摘要
Abstract
Insect odorant receptors(ORs)are core molecular determinants of volatile chemical signal detection in the peripheral olfactory system,playing pivotal roles in host localization,mate recognition,oviposition-site selection,and ecological adaptation.Early studies,through gene identification,expression profiling,electrophysiological characterization,and mutagenesis analyses,established the classical model in which ORs and the odorant receptor co-receptor(Orco)together form a functional ion channel complex.In recent years,advances in cryo-electron microscopy and protein structure prediction have enabled the successive resolution of Orco homotetrameric,OR homotetrameric,and OR-Orco heterotetrameric structures,substantially deepening our understanding of their assembly modes,ligand recognition,and gating mechanisms.This review systematically summarizes the discovery of insect ORs,the classical functional model,the process of structural elucidation,investigations into activation mechanisms,and their applications in evolutionary ecology,virtual screening,and biosensor development,while also highlighting future prospects for interdisciplinary applications.关键词
昆虫/气味受体/三维结构/配体识别机制/跨学科应用Key words
insect/odorant receptor/three-dimensional structure/ligand recognition mechanism/interdisciplinary applications分类
农业科技引用本文复制引用
张语桐,杨宇杰,王晓晴,王桂荣,刘杨..昆虫气味受体结构解析、机制探究与应用进展[J].中国生物防治学报,2026,42(2):305-316,12.基金项目
国家自然科学基金国际(地区)合作与交流项目(W2411023) （地区）
国家自然科学基金(32572938) （32572938）
中国农业科学院科技创新工程(CAAS-CSCB-202302) （CAAS-CSCB-202302）
