针灸临床杂志2026，Vol.42Issue(4)：48-57,10.DOI:10.19917/j.cnki.1005-0779.026070
针刺中风患者阳陵泉穴脑区激活——基于脑成像坐标的ALE元分析
Brain Activation in Stroke Patients Following Needling GB34:An ALE Meta-Analysis Based on Neuroimaging Coordinates
摘要
Abstract
Objective:To investigate the central mechanisms of brain activation in stroke patients following needling Yanglingquan(GB34)based on functional magnetic resonance imaging(fMRI)coordinate data,and to provide clinical evidence for acupuncture intervention in stroke rehabilitation.Methods:A systematic search was conducted in PubMed,Web of Science,Embase,The Cochrane Library,CNKI,CBM,VIP,and Wanfang databases for relevant Chinese and English studies published from inception to February 2025 involving functional magnetic resonance imaging(fMRI)of needling GB34 in stroke patients.Ginger ALE 3.0.2 software was used to calculate the activation likelihood estimation(ALE)of brain regions,and Mango 4.1 and MRIcroGL software were applied for visualization of the resulting brain maps.Results:A total of 10 studies were included,involving 201 participants(77 stroke patients and 124 healthy controls).The results demonstrated that needling GB34 modulated activation patterns primarily in the frontal lobe,temporal lobe,and cerebellum.Specifically,the activated brain regions included the postcentral gyrus,precentral gyrus,lentiform nucleus,caudate nucleus,precuneus,middle frontal gyrus,transverse temporal gyrus,inferior parietal lobule,cingulate gyrus,insula,cerebellar tonsil,inferior semilunar lobule,and cerebellar slope.Increased activation induced by needling GB34 in stroke patients was mainly located in the dominant hemisphere,whereas in healthy subjects it was predominantly located in the non-dominant hemisphere.This difference may be associated with post-stroke brain functional reorganization and compensatory mechanisms.Conclusion:Needling GB34 mainly activates brain regions involved in the sensorimotor network,default mode network,and cerebellar system.By specifically enhancing or inhibiting neural activity in key areas and modulating functional connectivity among these regions,acupuncture produces synergistic effects that facilitate compensatory regulation and reorganization of motor-related brain networks,thereby promoting the recovery of limb motor function.关键词
中风/针刺/阳陵泉/功能磁共振成像/ALE元分析Key words
Stroke/Acupuncture/GB34/fMRI/ALE meta-analysis分类
医药卫生引用本文复制引用
申艳,李媛媛,史昕玥,张琚崴,徐梦方,马任钊,孙熙蕊,林雨晴,邹忆怀..针刺中风患者阳陵泉穴脑区激活——基于脑成像坐标的ALE元分析[J].针灸临床杂志,2026,42(4):48-57,10.基金项目
国家自然科学基金,编号:82174331、81873257. （）
