生物资源2026，Vol.48Issue(2)：107-115,9.DOI:10.14188/j.ajsh.20260007
海洋活性物质的抗肿瘤作用机制与临床转化进展
Antitumor mechanisms and advances in clinical translation of marine bioactive substances
摘要
Abstract
Marine bioactive substances,characterized by novel structures,diverse chemical scaffolds,and significant biological activities,have become an important resource in anticancer drug research.Tumor initiation and progression in-volve multiple key processes,including abnormal cell proliferation,dysregulation of programmed cell death,development of drug resistance,invasion and metastasis,and remodeling of the tumor microenvironment.This article reviews the re-search progress of marine bioactive substances in cancer therapy,with a focus on their roles and underlying mechanisms in inducing tumor cell apoptosis,ferroptosis,and autophagy,reversing tumor drug resistance,inhibiting invasion and metas-tasis,and regulating the tumor microenvironment.Their potential in combination therapy and clinical translation is also discussed.Current studies indicate that these bioactive substances can interfere with tumor progression through multiple targets and pathways,showing considerable potential in improving therapeutic sensitivity,enhancing antitumor efficacy,and improving prognosis.Future research should further strengthen investigations into their mechanisms of action,phar-macodynamic evaluation,safety,and clinical application,so as to promote the development and application of marine bio-active substances in cancer prevention and treatment.关键词
海洋活性物质/抗肿瘤/耐药性/肿瘤微环境/侵袭与转移Key words
marine bioactive substances/antitumor/drug resistance/tumor microenvironment/invasion and metastasis分类
医药卫生引用本文复制引用
刘鑫,黄宇轩,王琳菲,侯可锐..海洋活性物质的抗肿瘤作用机制与临床转化进展[J].生物资源,2026,48(2):107-115,9.基金项目
国家自然科学基金项目(82151217 （）
81201088 （）
81472550) （）
