阿尔茨海默病及相关病2026，Vol.9Issue(3)：158-163,6.DOI:10.3969/j.issn.2096-5516.2026.03.003
轻度认知障碍患者心肺体适能的改变及其与认知功能的相关性研究
Changes in cardiorespiratory fitness in patients with mild cognitive impairment and correlation with cognitive dysfunction
摘要
Abstract
Objective:To investigate changes in cardiorespiratory fitness in patients with mild cognitive impairment(MCI)and their correlation with cognitive dysfunction.Methods:A total of 770 elderly patients hospitalized long-term at Zhongren Geriatric Care Hospital in Jinshan District,Shanghai,were screened from March 2024 to March 2025.Ultimately,91 individuals completed both neuropsychological assessments and cardiorespiratory fitness evaluations.Based on scores from the Montreal Cognitive Assessment-Basic(Moca-B),participants were divided into an MCI group(score 14～20,n=60)and a healthy control group(score 20～30,n=31).Global cognitive function was assessed using the Moca-B;cognitive subdomains were evaluated using the Digit Span Test,Trail Making Test,and Wechsler Digit Symbol Substitution Test.Cardiorespiratory fitness was assessed via grip strength(left and right hand),Timed Up and Go test,and limits of stability.Partial correlation analysis was used to explore the relationship between cardiorespiratory fitness and cognitive function in MCI patients.Results:Compared with the healthy control group,the MCI group showed statistically significant differences in years of education,Moca-B score,Trail Making Test-A,Symbol Digit Modalities Test,backward digit span,verbal fluency test,activities of daily living(ADL),grip strength(both hands),limits of stability,and TUG performance(P<0.05).Partial correlation analysis revealed a significant positive correlation between grip strength and cognitive function in MCI patients(P<0.001).Further analysis indicated that grip strength and limits of stability were independent risk factors affecting cognitive function in older adults.Conclusions:Patients with MCI exhibit measurable changes in cardiorespiratory fitness,among which grip strength is closely associated with cognitive function.Both grip strength and limits of stability may serve as early indicators of cognitive decline in older adults.关键词
轻度认知障碍/新肺体适能/认知功能/神经心理测评Key words
Mild cognitive impairment/Cardiorespiratory fitness/Cognitive function/Neuropsychological assessment分类
医药卫生引用本文复制引用
陈梅,张雅雯,孙力杨,盛志花,姚锋,姚红英,王刚,徐英..轻度认知障碍患者心肺体适能的改变及其与认知功能的相关性研究[J].阿尔茨海默病及相关病,2026,9(3):158-163,6.基金项目
上海市金山区第七周期医学重点专科"攀登计划"建设项目(JSZK2023B06) （JSZK2023B06）
上海市金山区卫生健康委员会项目(JSKJ-KTYIT-2024-03) （JSKJ-KTYIT-2024-03）
上海市金山区医药卫生科技创新资金项目(项目编号:2023-WS-63) （项目编号:2023-WS-63）
