阿尔茨海默病及相关病2026，Vol.9Issue(3)：204-210,7.DOI:10.3969/j.issn.2096-5516.2026.03.009
富含甘油三酯脂蛋白及其残粒在阿尔茨海默病合并心血管风险中的作用与防治
The role and management of triglyceride-rich lipoproteins and remnants in Alzheimer's disease with cardiovascular risk
金永合 1李武媚 1潘丽娟 1高亮1
作者信息
- 1. 河西学院附属张掖人民医院,甘肃 张掖 734000
- 折叠
摘要
Abstract
Dysregulated metabolism of triglyceride-rich lipoproteins(TRLs)and remnants constitutes a shared risk factor for both cardiovascular disease(CVD)and Alzheimer's disease(AD),with close pathological interconnections between the two conditions.This review synthesizes current evidence on the common mechanisms through which TRLs and their remnants contribute to both CVD and AD,primarily involving the promotion of atherosclerosis,induction of systemic and neuroinflammation,and exacerbation of insulin resistance.By integrating clinical and genetic findings,it highlights the potential bridging role of TRLs between cardiovascular risk and cognitive decline.Furthermore,the review summarizes advances and limitations of current management strategies including lifestyle interventions,conventional pharmacotherapy,and emerging treatments within the framework of cardiocerebral comorbidity.It proposes a patient-centered,multidisciplinary integrated care pathway aimed at optimizing the management of these co-occurring conditions.Future research should focus on novel targets within TRLs metabolism to develop more effective interventions and improve outcomes in this high-risk population.关键词
富含甘油三酯脂蛋白/残粒胆固醇/阿尔茨海默病/心血管疾病/心脑共病Key words
Triglyceride-rich lipoproteins/Remnant cholesterol/Alzheimer's disease/Cardiovascular disease/Cardiocerebral comorbidity分类
医药卫生引用本文复制引用
金永合,李武媚,潘丽娟,高亮..富含甘油三酯脂蛋白及其残粒在阿尔茨海默病合并心血管风险中的作用与防治[J].阿尔茨海默病及相关病,2026,9(3):204-210,7.
