阿尔茨海默病及相关病2026，Vol.9Issue(3)：211-216,封3,7.DOI:10.3969/j.issn.2096-5516.2026.03.010
帕金森病合并肌少症共病的研究进展
Recent progress in Parkinson's disease-sarcopenia comorbidity
摘要
Abstract
The comorbidity of Parkinson's disease(PD)and sarcopenia in the elderly has garnered increasing research interest in recent years.This condition can accelerate the decline of motor function and elevate the risk of falls.The underlying pathogenesis is multifactorial,involving processes such as neuroinflammation,oxidative stress,hormonal and metabolic dysregulation,mitochondrial dysfunction,neuromuscular junction impairment,gut microbiota dysbiosis,exosome-mediated propagation of α-synuclein pathology,non-motor symptoms,pharmacological effects,and neurodegeneration.Intervention strategies emphasize a multi-targeted,integrated management approach,including personalized resistance training,nutritional support,and innovative therapies targeting the gut microbiome.Despite accumulating evidence,considerable controversies remain regarding the pathogenic mechanisms,diagnostic criteria,and optimal interventions for this comorbidity.This review summarizes recent advances in the study of PD complicated by sarcopenia,aiming to inform strategies for improving functional outcomes and quality of life in affected patients.关键词
帕金森病/肌少症/病理机制Key words
Parkinson's disease/Sarcopenia/Pathological mechanisms分类
医药卫生引用本文复制引用
许晓辉,蔡卫卫..帕金森病合并肌少症共病的研究进展[J].阿尔茨海默病及相关病,2026,9(3):211-216,封3,7.基金项目
河南省医学科技攻关计划项目(LHGJ20230808) （LHGJ20230808）
洛阳市科技发展计划项目(2022025Y) （2022025Y）
