北华大学学报（自然科学版）2026，Vol.27Issue(2)：237-241,5.DOI:10.11713/j.issn.1009-4822.2026.02.010
柴芩颗粒对动物急性炎症的抗炎作用及机制
Anti-inflammatory Effect and Mechanisms of Chaiqin Granules on Acute Inflammation in Animals
摘要
Abstract
Objective To investigate the anti-inflammatory effect and mechanisms of Chaiqin Granules on acute inflammation in animals based on a pharmacodynamic evaluation system with three animal models.Methods Three inflammatory models were established,including xylene-induced ear edema in mice,acetic acid-induced increased peritoneal capillary permeability in mice,and carrageenan-induced paw edema in rats,to observe the anti-inflam-matory effect of Chaiqin Granules.Enzyme-linked immunosorbent assay(ELISA)was employed to detect the contents of IL-6,IL-17,IL-1β,IL-18,NLRP3 inflammasome and Caspase 1 in the serum and paw edema tissues of carrageenan-induced inflammatory rats.Results Compared with control group,medium and high-dose groups of Chaiqin Granules both inhibited xylene-induced ear edema in mice(P<0.01,P<0.05).Medium-dose group of Chaiqin Granules significantly suppressed acetic acid-induced increase in peritoneal capillary permeability in mice(P<0.05).High,medium and low-dose groups of Chaiqin Granules reduced the contents of inflammatory factors IL-6,IL-17 and IL-1β in rat serum to varying degrees(P<0.05,P<0.01,P<0.001),and simultaneously decreased the contents of IL-18,IL-1β,Caspase 1 and NLRP3 in paw tissues(P<0.05,P<0.01,P<0.001).Conclusion Chaiqin Granules have an inhibitory effect on acute inflammation.They can alleviate inflammatory responses by inhibiting the NLRP3 inflammasome signaling pathway,regulating the release of inflammatory factors IL-1β and IL-18,and reducing the levels of inflammatory factors IL-6,IL-17 and IL-1β in serum.关键词
柴芩颗粒/抗炎作用/炎症因子/机理Key words
Chaiqin Granules/anti-inflammatory effect/inflammatory factors/mechanism分类
医药卫生引用本文复制引用
林艳玲,王清,常燕,吴迪..柴芩颗粒对动物急性炎症的抗炎作用及机制[J].北华大学学报（自然科学版）,2026,27(2):237-241,5.基金项目
吉林省中医药科技项目(2024109). （2024109）
