湖南中医杂志2026，Vol.42Issue(4)：35-40,6.DOI:10.16808/j.cnki.issn1003-7705.2026.04.007
基于脑-肠轴理论采用隔面碗药灸脐法联合八卦揉腹干预心脾两虚型失眠40例
Clinical effect of medicated umbilical moxibustion with a bowl made of wheat flour combined with Bagua abdominal massage in treatment of insomnia with heart-spleen deficiency syndrome based on the brain-gut axis theory:An analysis of 40 cases
摘要
Abstract
Objective:To investigate the clinical effect of medicated umbilical moxibustion with a bowl made of wheat flour combined with Bagua abdominal massage in the treatment of insomnia with heart-spleen deficiency syndrome based on the brain-gut axis theory.Methods:A total of 120 insomnia patients with heart-spleen deficiency syndrome were enrolled and randomly divided into Western medicine group,umbilical moxibustion group,and combination group,with 40 patients in each group.The patients in the Western medicine group received estazolam,those in the umbilical mox-ibustion group received medicated umbilical moxibustion with a bowl made of wheat flour,and those in the combination group received medicated umbilical moxibustion with a bowl made of wheat flour combined with Bagua abdominal massage.The three groups were compared in terms of Pittsburgh Sleep Quality Index(PSQI)score,tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-1 β(IL-1 β),5-hydroxytryptamine(5-HT),norepinephrine(NE),and γ-aminobutyric acid(GABA),and clinical outcome was assessed.Results:The overall response rate was 87.5％(35/40)in the Western medicine group,60.0％(24/40)in the umbilical moxibustion group,and 85.0％(34/40)in the combination group,with a significant difference between the three groups(P＜0.05).All groups had significant changes in PSQI scores after intervention(P＜0.05);there was a significant difference in the use of hypnotic drugs between the umbilical moxibustion group and the Western medicine group and between the combination group and the Western medicine group(P＜0.05),while there was no significant difference between the umbilical moxibustion group and the combination group(P＞0.05);there were significant differences in the other scores between the Western medicine group and the umbilical moxibustion group and between the combination group and the umbilical moxibustion group(P＜0.05),while there were no significant differences between the Western medicine group and the combination group(P＞0.05).All three groups had significant changes in the levels of TNF-α,IL-6,IL-1 β,5-HT,NE,and GABA after intervention,with significant differences between the Western medicine group and the umbilical moxibustion group and between the combination group and the umbilical moxibustion group(P＜0.05),while there were no significant dif-ferences between the Western medicine group and the combination group after intervention(P＞0.05).Conclusion:For insomnia patients with heart-spleen deficiency syndrome,medicated umbilical moxibustion with a bowl made of wheat flour combined with Bagua abdominal massage can effectively alleviate symptoms and improve the levels of inflammatory factors and neurotransmitters,with a comparable clinical effect to oral administration of estazolam.关键词
失眠/心脾两虚型/脑-肠轴/中西医结合疗法/脐灸/八卦揉腹/艾司唑仑Key words
insomnia/heart-spleen deficiency syndrome/brain-gut axis/integrated traditional Chinese and West-ern medicine therapy/umbilical moxibustion/Bagua abdominal massage/estazolam分类
医药卫生引用本文复制引用
梁佳宁,彭小玉,刘婧雯,吴琴静,贺舒妍..基于脑-肠轴理论采用隔面碗药灸脐法联合八卦揉腹干预心脾两虚型失眠40例[J].湖南中医杂志,2026,42(4):35-40,6.基金项目
湖南省中医药管理局重点项目(C2024003) （C2024003）
