湖南中医杂志2026，Vol.42Issue(4)：41-46,6.DOI:10.16808/j.cnki.issn1003-7705.2026.04.008
木防己汤加味辅助治疗阳虚水泛型慢性肺源性心脏病30例
Clinical effect of Jiawei Mufangji decoction as an adjuvant therapy for chronic pulmonary heart disease with water overflowing due to Yang deficiency:An analysis of 30 cases
摘要
Abstract
Objective:To investigate the clinical effect of Jiawei Mufangji decoction as an adjuvant therapy for chronic pulmonary heart disease(CPHD)with water overflowing due to Yang deficiency.Methods:A total of 60 CPHD patients with water overflowing due to Yang deficiency were randomly divided into treatment group and control group,with 30 patients in each group.The patients in the control group received conventional Western medicine treatment,and those in the treatment group received Jiawei Mufangji decoction in addition to the treatment in the control group.The two groups were compared in terms of traditional Chinese medicine(TCM)syndrome score,arterial partial pressure of ox-ygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2),forced expiratory volume in 1 second(FEV1),forced expiratory volume in the first second/forced vital capacity(FEV1/FVC),N-terminal pro-brain natriuretic peptide(NT-proBNP),and New York Heart Association(NYHA)cardiac functional grading,and clinical outcome was as-sessed.Results:There was no significant difference in overall response rate between the treatment group and the control group[93.33％(28/30)vs 80.00％(24/30),P＞0.05].After treatment,both groups had significant reductions in TCM syndrome score and NT-proBNP and significant increases in PaO2 and FEV1(P＜0.05),and the treatment group had significantly better results than the control group(P＜0.05).After treatment,both groups had a significant reduction in PaCO2 and a significant increase in FEV1/FVC(P＜0.05),but the treatment group had a significantly better improve-ment in PaO2 only than the control group(P＜0.05).The treatment group had a significant change in cardiac functional grading after treatment,and there was a significant difference in cardiac functional grading between the two groups after treatment(P＜0.05).No drug-related discomfort was observed in either group.Conclusion:As an adjuvant therapy,Jia-wei Mufangji decoction has certain advantages and a favorable safety profile in the treatment of CPHD with water overflowing due to Yang deficiency and can significantly improve cardiac function parameters,possibly by improving cardiac function,alleviating cardiac load,and enhancing myocardial contractility.关键词
慢性肺源性心脏病/阳虚水泛型/木防己汤/中西医结合疗法/临床观察Key words
chronic pulmonary heart disease/water overflowing due to Yang deficiency/integrated traditional Chi-nese and Western medicine therapy/Mufangji decoction分类
医药卫生引用本文复制引用
刘颖,侯道瑞..木防己汤加味辅助治疗阳虚水泛型慢性肺源性心脏病30例[J].湖南中医杂志,2026,42(4):41-46,6.基金项目
湖南省湘潭市医学科研项目(2024-xtyx-88) （2024-xtyx-88）
