陆军军医大学学报2026，Vol.48Issue(10)：1289-1297,9.DOI:10.16016/j.2097-0927.202603037
个体化神经调控治疗癫痫的挑战与融合式未来
Personalized neuromodulation in epilepsy:navigating challenges toward a convergent future
摘要
Abstract
Approximately one-third of patients with epilepsy develop drug-resistant epilepsy,where conventional resective surgery faces stringent clinical limitations.Recent years have witnessed neuromodulation techniques emerging as clinical alternatives,offering new therapeutic prospects for this population,though suboptimal efficacy persists.Current neuromodulation paradigms are evolving from empirical to data-driven and model-driven approaches,progressing toward their deep integration.Data-driven methods leverage clinical multimodal data,such as stereoelectroencephalography,to identify pivotal nodes within individual epileptic networks,while model-driven approaches simulate and optimize intervention strategies through constructing a"digital twin brain model".This review systematically evaluates clinical evidence and individualized practices of implantable closed-loop technologies,alongside advances in noninvasive deep brain modulation techniques—exemplified by temporal interference stimulation—and their multimodal synergies.Crucially,we delineate the fundamental distinctions and complementary relationships between data-driven and model-driven paradigms,proposing a unified framework centered on"digital twin brain models"to establish a closed loop from empirical observations to mechanistic simulations and treatment outcome projections.Finally,we synthesize current challenges across technological,methodological,and clinical domains,aiming to provide a theoretical foundation and actionable roadmap for personalized precision neuromodulation in epilepsy.关键词
神经调控/癫痫/个体化治疗/数字孪生脑Key words
neuromodulation/epilepsy/personalized treatment/digital twin brain分类
医药卫生引用本文复制引用
张春青,吴炬..个体化神经调控治疗癫痫的挑战与融合式未来[J].陆军军医大学学报,2026,48(10):1289-1297,9.基金项目
国家自然科学基金面上项目(82571673) （82571673）
重庆市自然科学基金面上项目(CSTB2023NSCQMSX0216) （CSTB2023NSCQMSX0216）
重庆市中青年医学高端人才项目(2024GDRC013) Supported by the General Program of National Natural Science Foundation of China(82571673),the General Project of Natural Science Foundation of Chongqing(CSTB2023NSCQMSX0216)and the Project for Young and Middle-Aged Top Medical Talents of Chongqing(2024GDRC013). （2024GDRC013）
