南方医科大学学报2026，Vol.46Issue(5)：1053-1058,6.DOI:10.12122/j.issn.1673-4254.2026.05.08
静脉注射地塞米松可增强肋锁间隙入路臂丛神经阻滞效果:一项随机双盲单中心临床研究
Intravenous dexamethasone enhances efficacy of brachial plexus block via the costoclavicular space:a randomized,double-blind,single-center trial
摘要
Abstract
Objective To investigate the effect of intravenous 8 mg dexamethasone injection on the efficacy of ultrasound-guided brachial plexus block(BPB)with 20 mL 0.375%ropivacaine via the costoclavicular space(CCS).Methods Eighty-four patients(18-65 years,ASA I-II,and BMI 18-25 kg/m²)undergoing elective surgery below the elbow were randomized into two groups to receive ultrasound-guided BPB with 20 mL 0.375%ropivacaine via the CCS combined with intravenous injection of 8 mg(4 mL)dexamethasone(trial group)or 4 mL normal saline(control group).The mean arterial pressure(MAP)and heart rate(HR)were measured before block,at the end of block,and at the start of surgery,and the type of surgery,duration of surgery,and block onset time(T1)were recorded.After the operation,the patients were followed up for durations of sensory(T2)and motor(T3)block,patient's satisfaction with anesthesia,incidences of nausea and vomiting within 24 h,and incidences of nerve block-related adverse effects within one week.Results No significant difference in block onset time was found between the two groups(P>0.05).The patients in the trial group exhibited significantly prolonged T2 and T3(P<0.001)with higher anesthesia satisfaction(P<0.05).No significant differences were observed in postoperative adverse events between the two groups(P>0.05).Conclusion Intravenous 8 mg dexamethasone,which does not affect block onset time of BPB via the CCS,significantly prolongs the sensory and motor block durations and improves anesthesia satisfaction without significantly increasing the incidences of postoperative adverse events.关键词
罗哌卡因/肋锁间隙臂丛神经阻滞/地塞米松Key words
ropivacaine/costoclavicular brachial plexus block/dexamethasone引用本文复制引用
王爽,吴美珊,孙楠,林春水,陈莺,张超庭,邓凡,马欣,方海宏..静脉注射地塞米松可增强肋锁间隙入路臂丛神经阻滞效果:一项随机双盲单中心临床研究[J].南方医科大学学报,2026,46(5):1053-1058,6.基金项目
国家自然科学基金(82572476) （82572476）
广州市科技计划项目(2023A04J2420)Supported by National Natural Science Foundation of China(82572476). （2023A04J2420）
