腹腔镜外科杂志2026，Vol.31Issue(4)：274-279,6.DOI:10.13499/j.cnki.fqjwkzz.2026.04.274
亚麻醉剂量艾司氯胺酮联合丙泊酚对腹腔镜结直肠癌根治术后患者认知功能的影响
The effect of sub-anesthetic dose esketamine combined with propofol on cognitive function in patients undergoing laparoscopic radical resection of colorectal cancer
摘要
Abstract
Objective:To explore the application value of sub-anesthetic dose esketamine combined with propofol in laparosco-pic radical resection of colorectal cancer.Methods:A total of 110 patients who underwent laparoscopic radical resection for colorectal cancer from Jun.2022 to Dec.2024 were selected.The patients were divided into the observation group(n=55,receiving sub-anesthetic dose esketamine combined with propofol for anesthesia)and the control group(n=55,receiving conventional anesthesia)by envelope method.The related indicators of the two groups were compared and analyzed,including mean arterial pressure,heart rate at different time points,operation time,anesthesia time,intraoperative blood loss,mechanical ventilation time,post-anesthesia care unit stay time,recovery time,Montreal cognitive assessment scale score,incidence of postoperative cognitive impairment,tumor necrosis factor-a,C-reactive protein,and interleukin-6.Results:At 5 min after anesthesia,30 min after anesthesia and at the end of the operation,the mean arterial pressure of the observation group was higher than that of the control group(P<0.05);at 5 min after anesthesia and 30 min after anesthesia,the heart rate of the observation group was lower than that of the control group(P<0.05).There was no statistically signifi-cant difference between the two groups in operation time,anesthesia time,intraoperative blood loss,mechanical ventilation time,post-anesthesia care unit stay time,and recovery time(P>0.05).At 24 h after operation,the serum levels of tumor necrosis factor-α,C-reac-tive protein and interleukin-6 in the observation group were lower than those in the control group(P<0.05),and the Montreal cognitive assessment scale score was higher than that in the control group(P<0.05).The incidence of postoperative cognitive impairment in the observation group was lower than that in the control group(P<0.05).Within 24 h after operation,the effective pressing times and total pressing times of the analgesic pump in the observation group were fewer than those in the control group(P<0.05).Conclusions:The application of sub-anesthetic dose esketamine combined with propofol in laparoscopic radical resection of colorectal cancer can maintain the stability of patients'hemodynamics,reduce postoperative cognitive impairment,and is worthy of clinical promotion and application.关键词
结直肠肿瘤/结直肠癌根治术/腹腔镜检查/艾司氯胺酮/丙泊酚/亚麻醉剂量Key words
Colorectal neoplasms/Radical resection of colorectal cancer/Laparoscopy/Esketamine/Propofol/Subanesthetic dose分类
医药卫生引用本文复制引用
王二松,李海燕,杨宁,李超,杨静..亚麻醉剂量艾司氯胺酮联合丙泊酚对腹腔镜结直肠癌根治术后患者认知功能的影响[J].腹腔镜外科杂志,2026,31(4):274-279,6.基金项目
沧州市科技计划项目(213106080) （213106080）
