分析化学2026，Vol.54Issue(4)：614-623,10.DOI:10.19756/j.issn.0253-3820.261052
基于纳米标签的侧流免疫分析在滥用药物即时检测中的研究进展
Advances in Nanoparticle-based Lateral Flow Immunoassay for Point-of-Care Detection of Abuse Drugs
摘要
Abstract
The abuse of drugs,including narcotics and psychotropic substances,antibiotics,and additives,has become a significant threat to global public health security and social stability.Therefore,the development of rapid,efficient,portable,and on-site screening technologies suitable for resource-limited environments is of great importance for the early detection,effective regulation,and monitoring of trends in drug abuse.Lateral flow immunoassay(LFIA),leveraging its operational simplicity,rapid response,cost-effectiveness,and suitability for non-laboratory settings,has emerged as a pivotal platform for point-of-care testing(POCT)of abuse drugs.Among these,nanotags,serving as signal carriers,play a key role in enabling high-performance LFIA by conjugating antibodies to output detection signals.This review began with a brief introduction to LFIA technology,systematically summarized recent research progress in LFIA recognition mechanisms,novel nanolabels,and signal transduction strategies for drug abuse detection,and discussed the remaining challenges and future trends in this field.关键词
侧流免疫分析/滥用药物/纳米标签/信号读取与分析/评述Key words
Lateral flow immunoassay/Drugs abuse/Nanolabel/Signal readout and analysis/Review引用本文复制引用
李岩杰,加德拉·塔拉甫,张宗程,布麦丽娅·热合木江,李敏,孙健..基于纳米标签的侧流免疫分析在滥用药物即时检测中的研究进展[J].分析化学,2026,54(4):614-623,10.基金项目
国家自然科学基金项目(No.82504731)、新疆医科大学高层次人才启动项目和国家级科研创新人才培育项目(No.XYD2024GR03)资助. Supported by the National Natural Science Foundation of China(No.82504731),the High-level Talents Start-up Project of Xinjiang Medical University,and the National Research Innovation Talents Cultivation Project(No.XYD2024GR03). （No.82504731）
