摘要
Abstract
Cervical cancer is one of the most common malignancies among women worldwide,ranking fourth in both incidence and mortality,and it poses a significant threat to women's health globally.Brachytherapy plays a pivotal role in the comprehensive management of locally advanced cervical cancer(LACC),and the choice of applicator technique directly influences dose distribution to the target volume as well as radiation exposure to organs at risk(OARs).This article systematically reviews recent advances in brachytherapy techniques for LACC,including intracavitary brachytherapy(ICBT),interstitial brachytherapy(ISBT),and combined intracavitary/interstitial brachytherapy(IC/ISBT).The clinical applications and dosimetric characteristics of these approaches are summarized.By synthesizing evidence from multiple clinical studies,differences among these techniques in terms of target coverage,OAR dose sparing,and clinical outcomes are comparatively analyzed.Current evidences indicates that IC/ISBT demonstrates certain advantages over ICBT or ISBT alone in improving target dose coverage and reducing radiation exposure to OARs,particularly in patients with large or irregularly shaped tumors.However,as an invasive procedure,IC/ISBT is associated with potential complications,and its indications should be carefully evaluated based on tumor characteristics and individual patient conditions.In summary,there is currently no unified standard for the selection of brachytherapy techniques and applicators in the treatment of LACC.Future prospective studies and further dosimetric optimization strategies are warranted to clarify the role of different techniques in individualized treatment and to provide higher-quality evidence for clinical decision-making.关键词
宫颈肿瘤/近距离放射治疗/施源器/临床疗效/剂量学分析Key words
Uterine cervical neoplasms/Brachytherapy/Applicator/Clinical efficacy/Dosimetry分类
医药卫生
