感染、炎症、修复2026，Vol.27Issue(2)：111-114,4.DOI:10.3969/j.issn.1672-8521.2026.02.002
训练免疫:脓毒症防治的免疫调控新策略
Trained immunity:A novel immunomodulatory strategy for sepsis prevention and treatment
摘要
Abstract
Sepsis is a life-threatening syndrome triggered by infection,and characterized by a dysregulated host immune response.It remains a major challenge in critical care medicine with persistently high mortality rates.Traditional therapeutic strategies have focused mainly on anti-infection and organ support,offering limited interventions for the core pathological process of immune imbalance,leaving clinical efficacy in urgent need of breakthrough.In recent years,the concept of"trained immunity"and the ongoing elucidation of its molecular mechanisms have provided a novel theoretical foundation for the prevention and treatment of sepsis.Trained immunity refers to the ability of innate immune cells to develop enhanced or diminished secondary response capabilities after an initial stimulus,through metabolic reprogramming and epigenetic remodeling,thereby establishing a form of non-antigen-specific immune memory.This process may exert positive effects on sepsis management by enhancing host defense and improving pathogen clearance efficiency under certain conditions.This article systematically reviews the fundamental concepts and molecular mechanisms of trained immunity,with a focus on its role in the onset,progression,and outcome of sepsis.Furthermore,it explores novel therapeutic strategies based on the modulation of trained immunity,aiming to provide a theoretical basis and new perspectives for precise immunotherapy in sepsis.关键词
训练免疫/脓毒症/免疫调控/代谢重编程/表观遗传修饰Key words
trained immunity/sepsis/immune regulation/metabolic reprogramming/epigenetic modification引用本文复制引用
刘靖华..训练免疫:脓毒症防治的免疫调控新策略[J].感染、炎症、修复,2026,27(2):111-114,4.基金项目
国家自然科学基金资助项目(82472199) （82472199）
