国际老年医学杂志2026，Vol.47Issue(3)：302-307,6.DOI:10.3969/j.issn.1674-7593.2026.03.007
共病指数与急性冠状动脉综合征患者冠状动脉病变程度及早期预后的相关性
Correlation study between comorbidity index and the degree of coronary artery lesions and early prognosis in patients with acute coronary syndrome
摘要
Abstract
Objective To investigate the relationship between the comorbidity index and the degree of coronary artery le-sions as well as early prognosis in patients with acute coronary syndrome(ACS).Methods A retrospective analysis was conducted on 169 ACS patients who underwent percutaneous coronary intervention(PCI)at Jinling Hospital between October 2023 and November 2024.Clinically relevant data was collected,and the Charlson comorbidity index(CCI)was calculated.The Gensini score was used to evaluate the degree of coronary artery lesions in patients.To statistically analyze the occurrence of major adverse cardiovascular e-vents(MACEs)during the hospitalization of patients.The spearman correlation test was used to evaluate the correlation between the CCI score and the degree of coronary artery lesions as well as the occurrence of MACEs.Multivariate logistic regression model was used to analyze the risk factors of MACEs during hospitalization,and the ROC curve was used to evaluate the predictive ability of CCI score for the occurrence of MACEs.Results 40 cases of MACEs occurred during hospitalization,while 129 cases did not.The MACEs group showed significantly higher values than the non-MACEs group in terms of age,prevalence of diabetes,white blood cell count,blood urea nitrogen,CCI score,Gensini score,number of diseased coronary branches,and number of implanted coronary stents(P<0.05).Spearman correlation analysis revealed that the CCI score was positively correlated with the Gensini score,number of diseased coronary branches,number of implanted stents,and the occurrence of MACEs in ACS patients(P<0.05).Logistic regression analysis indicated that the CCI score is an independent risk factor for MACEs in ACS patients(OR=5.364,95%CI:2.625-10.962,P<0.001).ROC curve analysis demonstrated that the area under the curve(AUC)for predicting MACEs using the CCI score was 0.878(95%CI:0.820-0.937,P<0.001),with a maximum Youden index of 0.608,sensitivity of 82.5%,specificity of 78.3%,and an optimal cutoff value of 2.5 scores.Conclusion The CCI is associated with the degree of coronary artery lesions and the occurrence of MACEs in ACS patients.Different preventive measures should be implemented based on patients'CCI stratification.关键词
急性冠状动脉综合征/查尔斯共病指数/冠状动脉病变程度/主要不良心血管事件Key words
Acute coronary syndrome/Charlson comorbidity index/Degree of coronary artery lesions/Major adverse cardi-ovascular events引用本文复制引用
王清清,陈阳希,贡歌,杨晨..共病指数与急性冠状动脉综合征患者冠状动脉病变程度及早期预后的相关性[J].国际老年医学杂志,2026,47(3):302-307,6.基金项目
江苏省老年健康科研项目(LD2022001) （LD2022001）
东部战区总医院基础研究计划一般项目(22JCYYYB6) （22JCYYYB6）
