医学分子生物学杂志2026，Vol.23Issue(3)：308-315,8.DOI:10.3870/j.issn.1672-8009.2026.03.010
SIRT1在肝脏疾病中的作用及研究进展
Research Progress on Roles of SIRT1 in Hepatic Diseases
摘要
Abstract
Silent information regulator 1(SIRT1),a core member of the Sirtuin family,is an NAD+-dependent class Ⅲ histone deacetylase that plays a crucial role in the epigenetic regulatory net-work.By mediating the deacetylation of a variety of histone and non-histone substrates,SIRT1 broadly regulates key physiological processes such as lipid metabolism,oxidative stress,inflammatory re-sponse,and apoptosis.Current studies indicate that dysregulation or functional impairment of SIRT1 is closely associated with the occurrence and progression of liver diseases.This article summarizes the specific mechanisms of SIRT1 in alcohol-associated liver disease,metabolic dysfunction-associated steatotic liver disease,viral hepatitis,liver fibrosis,and hepatocellular carcinoma.Additionally,the potential applications of SIRT1-targeted interventions in the treatment of chronic liver diseases are briefly discussed,with the aim of providing deeper insights into its unique regulatory mechanisms and offering a theoretical basis for developing more precise therapeutic strategies.关键词
沉默信息调节因子1/酒精相关性肝病/代谢功能障碍相关脂肪性肝病/肝纤维化/病毒性肝炎/肝细胞癌Key words
silent information regulator 1/alcohol-associated liver disease/metabolic dys-function-associated steatotic liver disease/liver fibrosis/viral hepatitis/hepato-cellular carcinoma分类
医药卫生引用本文复制引用
李玎嘉,张钰婷,刘亮明..SIRT1在肝脏疾病中的作用及研究进展[J].医学分子生物学杂志,2026,23(3):308-315,8.基金项目
国家自然科学基金(No.81770612、No.81070357),上海市松江区公共卫生体系建设三年行动计划(No.SJGW6-08) This work was supported by grants from the National Natural Science Foundation of China(No.81770612,No.81070357),the Three-Year Ac-tion Plan for the Construction of the Public Health System in Shanghai Songjiang District(No.SJGW6-08). （No.81770612、No.81070357）
