国际神经病学神经外科学杂志2026，Vol.53Issue(2)：46-61,16.DOI:10.16636/j.cnki.jinn.1673-2642.2026.02.007
脑磁图在神经科学中的前沿临床应用
Frontiers in the clinical application of magnetoencephalography in neuroscience
龚子涵 1王国伟 1毛宇 2饶誉鑫 1李俊俊 1姜晓兵 1陈风 3姜浩东 1汪珉杰 1余少杰 1李旭东 1张宝文 1马允堃 1杨成红1
作者信息
- 1. 华中科技大学同济医学院附属协和医院神经外科,湖北 武汉 430022
- 2. 郑州大学第一附属医院神经外科,河南 郑州 450003
- 3. 中南大学湘雅医院神经外科,湖南 长沙 410008
- 折叠
摘要
Abstract
Magnetoencephalography(MEG)is a noninvasive functional neuroimaging modality that achieves millisecond temporal resolution by recording the faint magnetic fields generated by neurons.Compared with electroencephalography(EEG),MEG is more sensitive to the tangential currents in the cerebral sulci and can perform source localization with better accuracy and stability.Traditional superconducting quantum interference device systems are bulky and reliant on cryogenic liquid helium,while the novel optically pumped magnetometer(OPM)systems are wearable and can operate at room temperature and enhance signal-to-noise ratios,thereby holding promise for wide clinical application.In terms of clinical application,MEG can localize epileptogenic foci that are not detected by EEG during preoperative epilepsy evaluation and improve the precision of resection through markers such as high frequency oscillations.For preoperative brain tumor management,MEG accurately delineates motor and language functional areas,avoids the issue of neurovascular uncoupling(NVU)caused by tumors,and helps to achieve safe resection with a larger extent in combination with image navigation.MEG can also detect early EEG spectral changes in the brain of patients with Alzheimer's disease and is thus used as a biomarker for evaluating the efficacy of new therapies.In Parkinson's disease,pathological beta oscillations revealed by MEG are correlated with the severity of motor symptoms,and the synchronized MEG-deep brain stimulation analysis can optimize stimulation targets and parameters.In autism spectrum disorder(ASD),MEG(especially OPM-based MEG)can effectively overcome compliance challenges in sensory-sensitive and pediatric populations,accurately capture excitation/inhibition imbalance and γ oscillation abnormalities,and promote the paradigm shift to the precise diagnosis and treatment of ASD based on objective neurophysiological biomarkers.With the development of OPM technology,MEG is playing an increasingly critical role in localization,surgical guidance,early diagnosis,and treatment optimization,thereby continuously promoting the precise diagnosis and treatment of neurological disorders.关键词
脑磁图/光泵磁力计/功能神经成像/生物标志物/癫痫/脑肿瘤/阿尔茨海默病/帕金森病/孤独症谱系障碍Key words
magnetoencephalography/optically pumped magnetometer/functional neuroimaging/biomarker/epilepsy/brain tumor/Alzheimer's disease/Parkinson's disease/autism spectrum disorder分类
医药卫生引用本文复制引用
龚子涵,王国伟,毛宇,饶誉鑫,李俊俊,姜晓兵,陈风,姜浩东,汪珉杰,余少杰,李旭东,张宝文,马允堃,杨成红..脑磁图在神经科学中的前沿临床应用[J].国际神经病学神经外科学杂志,2026,53(2):46-61,16.
