国际神经病学神经外科学杂志2026，Vol.53Issue(2)：69-75,7.DOI:10.16636/j.cnki.jinn.1673-2642.2026.02.009
瓦尔堡效应在胶质母细胞瘤代谢机制中的研究进展
Research advances in the metabolic mechanism of the Warburg effect in glioblastoma
张福龙 1曹培立 1李军伟 1赵晋东 1李荔荣1
作者信息
- 1. 山西医科大学附属山西省人民医院神经外科,山西 太原 030012
- 折叠
摘要
Abstract
The Warburg effect is associated with the metabolic mechanism of malignant tumors,and through metabolic reprogramming,it supplies energy and provides a conducive microenvironment for the rapid growth and metastasis of glioblastoma(GBM)cells,while helping them to escape apoptosis.An increasing number of studies have revealed the significance of the Warburg effect in the metabolic mechanism of GBM,especially the pivotal role of alterations in enzymatic pathways and related proteins in tumor progression.This article reviews the recent research advances in the metabolic mechanism of the Warburg effect in GBM,with a focus on the role of glycolysis-related enzymes and proteins and their impact on tumor growth,invasion,and drug resistance,in order to provide new ideas for further exploration of the therapeutic strategies for GBM.关键词
癌/胶质母细胞瘤/瓦尔堡效应/代谢机制/酶学Key words
carcinoma/glioblastoma/Warburg effect/metabolic mechanism/enzymology分类
医药卫生引用本文复制引用
张福龙,曹培立,李军伟,赵晋东,李荔荣..瓦尔堡效应在胶质母细胞瘤代谢机制中的研究进展[J].国际神经病学神经外科学杂志,2026,53(2):69-75,7.
