国际神经病学神经外科学杂志2026，Vol.53Issue(2)：76-82,7.DOI:10.16636/j.cnki.jinn.1673-2642.2026.02.010
闪光视觉诱发电位、视神经鞘直径、白细胞介素6及白细胞介素8在重症脑血管病中的应用研究进展
Research progress on the application of flash visual evoked potential,optic nerve sheath diameter,interleukin-6,and interleukin-8 in severe cerebrovascular disease
摘要
Abstract
With the continuous increase in the incidence of cerebrovascular diseases,the occurrence of severe cerebrovascular disease(SCVD),the most severe form of cerebrovascular diseases,has also been increasing year by year,posing great challenges to clinical treatment.Multimodal monitoring plays an increasingly prominent role in the treatment of SCVD,among which intracranial pressure(ICP)monitoring is a key approach to optimizing treatment outcomes and improving prognosis.Although invasive ICP monitoring is regarded as the gold standard,its widespread application is limited by its high risk and cost.Non-invasive ICP monitoring techniques,such as flash visual evoked potential and optic nerve sheath diameter,have shown good application potential and enable real-time dynamic assessment of ICP changes.Moreover,inflammatory factors such as interleukin-6 and interleukin-8 are involved in the pathophysiological process of SCVD,and changes in their serum levels are closely related to disease progression and prognosis.Based on existing literature,this article reviews the research progress in the application of two non-invasive ICP monitoring techniques(flash visual evoked potential and optic nerve sheath diameter)and two inflammatory factors(interleukin-6 and interleukin-8)in SCVD,analyzes their correlations and the potential value of their combined application,explores the significance of integrating them into the multimodal monitoring system for SCVD,and points out the deficiencies of current research,so as to provide a reference for subsequent clinical research and prognosis prediction model construction.关键词
重症脑血管病/颅内压/炎症因子/闪光视觉诱发电位/视神经鞘直径/白细胞介素6/白细胞介素8Key words
severe cerebrovascular disease/intracranial pressure/inflammatory factors/flash visual evoked potential/optic nerve sheath diameter/interleukin-6/interleukin-8分类
医药卫生引用本文复制引用
骆林正,李娜,赵怡,刘懿景,王荣蓉,曹淋曼,李博慈,李明玉,左纯,赵明敏..闪光视觉诱发电位、视神经鞘直径、白细胞介素6及白细胞介素8在重症脑血管病中的应用研究进展[J].国际神经病学神经外科学杂志,2026,53(2):76-82,7.基金项目
国家科技创新2030-"脑科学与类脑研究"重大项目(2021ZD0201807) （2021ZD0201807）
河北省临床医学优秀人才政府资助项目(ZF2023186) （ZF2023186）
河北省医学科学研究计划(20230314). （20230314）
