神经损伤与功能重建2026，Vol.21Issue(5)：249-254,6.DOI:10.16780/j.cnki.sjssgncj.20251531
Tafa2缺失促进脑缺血后小胶质细胞向抗炎表型转化、减轻神经损伤与功能障碍
Tafa2 Deficiency Promotes Microglial Anti-inflammatory Polarization and Attenuates Neurological Damage and Dysfunction after Ischemic Stroke
摘要
Abstract
Objective:To investigate the effects of Tafa2 on microglial functional phenotypes,neuronal injury,and functional recovery following acute cerebral ischemia.Methods:Transient middle cerebral artery occlusion(tMCAO)models were established in adult male wild-type mice.The spatiotemporal expression pattern of Tafa2 protein after cerebral ischemia was determined using immunofluorescence techniques.tMCAO models were established in adult male wild-type and Tafa2-knockout mice.The effects of Tafa2 deletion on microglial polarization,neuronal apoptosis,and neurological function during the acute phase of cerebral ischemia were assessed using immunofluorescence,Nissl staining,TUNEL staining,and behavioral tests.Results:In wild-type mice,Tafa2 protein expression was significantly increased in the ischemic hemisphere on day 3 after tMCAO compared to that in the sham group.On day 3 after tMCAO,Tafa2-knockout mice exhibited reduced infarct volume,decreased neuronal apoptosis,and alleviated sensorimotor deficits compared to wild-type mice.3 days after tMCAO,Tafa2-knockout mice showed an increased proportion of CD206+microglia and enhanced phagocytic function compared to wild-type mice.Conclusion:Tafa2 deficiency promotes the polarization of microglia toward an anti-inflammatory and pro-repair phenotype,reduces neuronal damage and improves neurological function during the acute phase of ischemic stroke.关键词
缺血性脑卒中/Tafa2/小胶质细胞/神经炎症Key words
ischemic stroke/Tafa2/microglia/neuroinflammation分类
医药卫生引用本文复制引用
冯林玉,李萍,王瑶,许元,徐亚萍,谢敏杰..Tafa2缺失促进脑缺血后小胶质细胞向抗炎表型转化、减轻神经损伤与功能障碍[J].神经损伤与功能重建,2026,21(5):249-254,6.基金项目
国家自然科学基金(组蛋白乳酸化诱导的小胶质细胞重编程在脑缺血后小胶质细胞功能调节与神经损伤与功能重塑中的作用及分子机制研究,No.82471348) （组蛋白乳酸化诱导的小胶质细胞重编程在脑缺血后小胶质细胞功能调节与神经损伤与功能重塑中的作用及分子机制研究,No.82471348）
