神经损伤与功能重建2026，Vol.21Issue(5)：255-260,6.DOI:10.16780/j.cnki.sjssgncj.20240707
运动习惯与帕金森病轻度认知障碍的关联路径分析
Analysis of the Association Pathways Between Exercise Habits and Mild Cognitive Impairment in Parkinson Disease
汤若男 1王淼 1尹西 1王振福 1高中宝 1王玉玲2
作者信息
- 1. 解放军总医院第二医学中心神经内科国家老年疾病临床研究中心 北京 100853
- 2. 解放军总医院卫勤训练中心 北京 100853
- 折叠
摘要
Abstract
Objective:To construct a structural equation model and analyze the impact pathways of exercise habits on mild cognitive impairment in Parkinson disease(PD-MCI).Methods:A cross-sectional study was conducted,involving 151 PD patients who visited the Parkinson's Disease Clinic at the Chinese PLA General Hospital in Beijing from October 2021 to June 2023.Patients were surveyed using a general information questionnaire,the Montreal Cognitive Assessment(MoCA),Part Ⅲ of the Unified Parkinson's Disease Rating Scale(UPDRS-Ⅲ),the Parkinson's Disease Sleep Scale-2(PDSS-2),and the Hamilton Depression Scale(HAMD).Mplus 8.3 software was used for association pathway analysis.Results:Both direct and indirect association pathways between exercise habits and the diagnostic risk of PD-MCI were significant(P＜0.05).These pathways included:exercise habits→PD-MCI(—0.153[—0.305,—0.006]),exercise habits→motor sym-ptoms→PD-MCI(—0.070[—0.129,—0.029]),exercise habits→motor symptoms→depressive symptoms→PD-MCI(—0.025[—0.051,—0.011]),exercise habits→motor symptoms→sleep quality → PD-MCI(—0.011[—0.028,—0.003]),and exercise habits→depressive symptoms→PD-MCI(—0.030[—0.067,—0.005]).Con-clusion:Exercise habits can directly predict the diagnostic risk of PD-MCI.They can also indirectly predict the diagnostic risk of PD-MCI through the mediating effects of motor symptoms and depressive symptoms,as well as through the chained mediating effects of motor symptoms combined with depressive symptoms or sleep quality.关键词
帕金森病/轻度认知障碍/运动/路径分析Key words
Parkinson disease/mild cognitive impairment/exercise/path analysis分类
医药卫生引用本文复制引用
汤若男,王淼,尹西,王振福,高中宝,王玉玲..运动习惯与帕金森病轻度认知障碍的关联路径分析[J].神经损伤与功能重建,2026,21(5):255-260,6.
