河北中医2026，Vol.48Issue(5)：727-731,5.DOI:10.3969/j.issn.1002-2619.2026.05.005
支气管哮喘患者中医证候与血清骨膜蛋白、肺功能的相关性研究
Correlations between TCM syndrome patterns,serum periostin,and pulmonary function in patients with bronchial asthma
摘要
Abstract
Objective To characterize serum periostin and pulmonary function changes in bronchial asthma patients,describe their traditional Chinese medicine(TCM)syndrome patterns,and analyze correlations between these TCM patterns and periostin levels and pulmonary function.Methods We enrolled 197 patients with bronchial asthma as the study group and clas-sified them into four TCM syndrome patterns.A contemporaneous control group comprised 187 healthy individuals.Serum periostin and pulmonary function parameters,including peak expiratory flow(PEF),forced expiratory volume in 1 second(FEV1),forced vital capacity(FVC),and maximal mid-expiratory flow(MMEF75/25),were measured and compared across groups.ROC curve analysis assessed the diagnostic performance of periostin and pulmonary function indices for bronchial asthma.Pearson correlation analysis evaluated relationships between TCM syndrome patterns and periostin and pulmonary function.Results Compared with controls,asthma patients had significantly higher serum periostin and significantly lower FEV1,MMEF75/25,FVC,and PEF(P<0.05).Combined testing(FEV1,periostin,MMEF75/25,PEF,FVC)yielded sensitivity of 93.91%,AUC of 0.843,accuracy of 78.39%,and 95%CI 0.805～0.882,outperforming individual measures.Among the 197 patients,distribution of TCM patterns was:heat-type 80(40.61%),wind-type 48(24.37%),cold-type 44(22.34%),and deficiency-type 25(12.69%).Relative to the heat-type group,the wind-,cold-,and deficiency-type groups demonstrated lower periostin levels and higher FEV1,PEF,ACT score,MMEF75/25,and FVC.Relative to the wind-type group,the cold-and deficiency-type groups showed further increases in FVC,PEF,ACT score,FEV1,and MMEF75/25 and reductions in periostin.Compared with the cold-type group,the deficiency-type group had higher FEV1,PEF,MMEF75/25,FVC,and ACT score and lower periostin;all differences reached statistical significance(P<0.05).Pearson correlation analysis indicated that the presence of the listed TCM patterns(wind-,deficiency-,heat-,and cold-type)was positively associated with periostin and negatively associated with PEF,FVC,MMEF75/25,and FEV1(P<0.05).Conclusion In bronchial asthma,the predominant TCM syndrome patterns are heat-,wind-,cold-,and deficiency-type.These patients exhibit elevated serum periostin and impaired pulmonary function,and distinct TCM patterns correspond to different periostin and pulmonary function profiles.关键词
支气管哮喘/中医证候/骨膜蛋白/肺功能Key words
Bronchial asthma/Traditional Chinese medicine syndrome patterns/Periostin/Pulmonary function分类
医药卫生引用本文复制引用
刘芳,周旋,宋晓娟..支气管哮喘患者中医证候与血清骨膜蛋白、肺功能的相关性研究[J].河北中医,2026,48(5):727-731,5.基金项目
南京市卫生健康委员会医药卫生科研课题(编号:YKK24238) （编号:YKK24238）
