哈尔滨医药2026，Vol.46Issue(2)：19-22,4.DOI:10.3969/j.issn.1001-8131.2026.02.005
哮喘和慢阻肺及哮喘-慢阻肺重叠综合征患者生物学标志物的比较分析
Comparison of Biomarkers in Asthma COPD and Asthma-COPD Overlap
摘要
Abstract
Objective To compare biomarkers in asthma,COPD,and asthma-COPD overlap(ACO).Methods 50 patients per group(asthma,COPD,ACO,and healthy controls)were included.Inflammatory,protease-related,and fibrotic biomarkers were analyzed.Correlation analysis assessed biomarker-disease associations.Results Eosinophilic markers(FeNO,IL-5)were highest in asthma,neutrophil/protease markers(MMP-9,NE)in COPD,and TGF-β in ACO.FeNO correlated strongly with asthma,MMP-9 with COPD,and TGF-β most strongly with ACO.Conclusion Asthma shows eosinophilic inflammation,COPD exhibits neutrophilic inflammation and oxidative stress,while ACO combines features of both with a distinct pro-fibrotic profile.关键词
哮喘/慢性阻塞性肺疾病/哮喘-慢阻肺重叠综合征/生物标志物Key words
Asthma/COPD/Asthma-COPD Overlap/Biomarkers分类
医药卫生引用本文复制引用
姚智慧,刘兴东,谢君英..哮喘和慢阻肺及哮喘-慢阻肺重叠综合征患者生物学标志物的比较分析[J].哈尔滨医药,2026,46(2):19-22,4.基金项目
湘南学院附属衡阳医院专项项目(202411807) （202411807）
