湖南中医药大学学报2026，Vol.46Issue(3)：643-650,8.DOI:10.3969/j.issn.1674-070X.2026.03.029
冠心病的中医药择时干预策略研究进展
Research progress on chrono-intervention strategies of TCM for coronary heart disease
摘要
Abstract
Circadian rhythm is an inherent physiological mechanism in living organisms,and its disruption is closely associated with the occurrence and development of cardiovascular diseases such as coronary heart disease(CHD).Significant differences in circadian rhythms exist across different CHD subtypes:stable angina pectoris exhibits a peak incidence between 9:00 and 12:00,with a 3.0-fold increase in relative risk;unstable angina pectoris demonstrates a high incidence period that shifts earlier to 6:00–12:00,closely aligning with the time window of atherosclerotic plaque rupture;notably,patients with acute myocardial infarction in China show a unique bimodal distribution,contrasting with the morning unimodal pattern in Western populations.The chrono-intervention of TCM based on the midnight-noon ebb-flow theory,combining the temporal rules of qi and blood circulation with the onset characteristics of different subtypes,can effectively alleviate clinical symptoms and improve the quality of life of patients through methods such as chrono-medication,acupuncture,acupoint application,and moxibustion.Relevant studies have confirmed the differential application value of the midnight-noon ebb-flow theory in CHD,providing a theoretical basis for precise chronotherapy,and reflecting the significance of the TCM concept of"man-nature unity"in personalized medicine.关键词
冠心病/昼夜节律/子午流注/中医药择时干预/差异化应用Key words
coronary heart disease/circadian rhythm/midnight-noon ebb-flow/chrono-intervention of TCM/differential application分类
医药卫生引用本文复制引用
刘映志,于子璇,陆玉雯,柳岳,陈偶英,李杰..冠心病的中医药择时干预策略研究进展[J].湖南中医药大学学报,2026,46(3):643-650,8.基金项目
国家自然科学基金项目(81874375) （81874375）
湖南省自然科学基金项目(2023JJ30452,2024JJ8236) （2023JJ30452,2024JJ8236）
湖南省卫生健康委员会科研重点课题(20254078) （20254078）
湖南中医药大学研究生创新课题(2024CX152,2024CX151,2024CX150). （2024CX152,2024CX151,2024CX150）
