化学试剂2026，Vol.48Issue(5)：22-31,10.DOI:10.13822/j.cnki.hxsj.2026.0044
香豆素类药物药理活性研究进展
Research Progress in Molecular Activity of Coumarin-Related Drugs
摘要
Abstract
Coumarin compounds are secondary metabolites formed by the fusion of a benzene ring and an α-pyrone ring,belonging to the class of ortho-hydroxycinnamic acid lactones,which are widely distributed in nature.Coumarins have attracted considerable attention owing to their rich pharmacological activity and potential for treating various diseases,with applications in natural products,drug design and development,and overall health.For many years,researchers have studied coumarins in depth,introducing various functional groups,such as pyran,sesquiterpene,alkylamine,nitro,aromatic,piperazine,acrylate,and trifluoromethyl groups,into their parent ring structure.Several coumarin drugs-particularly antibacterial and antitumor drugs-have been successfully used to treat various diseases,demonstrating their rich pharmacological activity and high clinical value.This review summarized the research progress of coumarin drugs with therapeutic activities,including anticoagulation,antibacterial,and antitumor effects,based on drug databases and domestic and foreign literature.This study provides an outlook on the development prospects of coumarin drugs,aiming to provide a reference for further research,development,and application.关键词
香豆素/药理活性/研究进展/抗菌/抗肿瘤Key words
coumarin/pharmacological activity/research progress/antibacterial/antitumor分类
化学化工引用本文复制引用
刘帝,万明涛,路文涛,王丹,叶文强,门靖..香豆素类药物药理活性研究进展[J].化学试剂,2026,48(5):22-31,10.基金项目
陕西省重点研发计划项目(2022SF-570). （2022SF-570）
