miR-141在恶性肿瘤诊断、预后及靶向治疗中的作用研究进展
Research progress on the role of miR-141 in the diagnosis,prognosis,and targeted therapy of malignant tumors
摘要
Abstract
MicroRNAs(miRNAs)are a class of small non-coding RNAs consisting of 18-25 nucleotides that participate in various biological processes,including cell proliferation,differentiation,and apoptosis,by regulating the expression of target genes.As a key tumor-suppressive miRNA,miR-141 plays a central regulatory role in the occurrence and progression of multiple malignant tumors.It can directly target key molecules such as zinc finger E-box-binding homeobox 1/2(ZEB1/2),phosphatase and tensin homolog deleted on chromosome 10(PTEN),and B-cell-specific moloney murine leukemia virus insertion site 1(BMI1),and regulate signaling pathways including epithelial-mesenchymal transition(EMT),PTEN/protein kinase B-glycogen synthase kinase 3β(Akt-GSK3β),and Wnt/β-catenin.Through these mechanisms,miR-141 inhibits the proliferation of malignant tumor cells,promotes apoptosis,and blocks their invasion,metastasis,and angiogenesis,participating in the entire regulatory process of the occurrence and development of malignant tumors.miR-141 is expected not only to serve as a potential molecular biomarker for early diagnosis and prognosis evaluation of malignant tumors,providing new directions for precise diagnosis and treatment,but also to act as a therapeutic target,restoring its expression can enhance the efficacy of chemotherapy and targeted drugs and improve patient prognosis.This review summarizes the research progress of miR-141 in the diagnosis,prognosis,and targeted therapy of malignant tumors,aiming to provide a reference for the clinical treatment of malignant tumors.关键词
miR-141/恶性肿瘤/作用机制/临床价值/治疗靶点Key words
miR-141/malignant tumors/mechanism of action/clinical value/therapeutic target分类
医药卫生引用本文复制引用
马玉嫆,张敏,王康乐,孙田思,陈璇羽,王欣怡,王波波,王逢会..miR-141在恶性肿瘤诊断、预后及靶向治疗中的作用研究进展[J].解放军医学杂志,2026,51(4):512-521,10.基金项目
This work was supported by the National Natural Science Foundation of China(32360891,82360554,81860444),the Special Scientific Research Program for Serving Local Development of Shaanxi Provincial Department of Education(24JC087),the Science and Technology Plan Project of Yan'an City(2024-NYGG-125),the Independent Research Project of Shaanxi Key Laboratory of Chinese Jujube(sxhzdsys-zj23-01),the Yan'an Education,Science and Culture Development Foundation(YAU202510700),and the Doctoral Research Startup Project of Yan'an University(YDBK2022-18) 国家自然科学基金(32360891,82360554,81860444) （32360891,82360554,81860444）
陕西省教育厅服务地方专项科学研究计划项目(24JC087) （24JC087）
延安市科技计划项目(2024-NYGG-125) （2024-NYGG-125）
陕西省红枣重点实验室自主研究课题(sxhzdsys-zj23-01) （sxhzdsys-zj23-01）
延安教科文发展基金(YAU202510700) （YAU202510700）
延安大学博士科研启动项目(YDBK2022-18) （YDBK2022-18）
