解放军医学杂志2026，Vol.51Issue(4)：522-530,9.DOI:10.11855/j.issn.0577-7402.2161.2026.0105
靶向自噬调控消化道肿瘤化疗耐药性的研究进展
Advances in targeting autophagy to overcome chemotherapy resistance in gastrointestinal tumors
摘要
Abstract
Chemotherapy is a common treatment for cancer;however,its efficacy is often significantly limited by the development of drug resistance.Gastrointestinal tumors are among the most common malignancies worldwide,and overcoming chemoresistance is crucial for improving patient prognosis.Autophagy,a catabolic process that maintains cellular homeostasis,plays a dual role in the drug resistance of gastrointestinal tumors.On one hand,protective autophagy contributes to the development of chemoresistance;on the other hand,excessive or sustained autophagy may induce autophagic cell death,thereby reversing drug resistance.Therefore,the targeted modulation of autophagy has emerged as a promising strategy to counteract chemoresistance.This review begins with an overview of the classification and fundamental processes of autophagy,systematically elucidates its bidirectional regulatory function in gastrointestinal tumor chemoresistance,and summarizes recent advances in targeting autophagy via autophagy inhibitors or activators to overcome chemoresistance,aiming to provide new insights and rationale for anticancer therapy in gastrointestinal tumors.关键词
自噬/耐药性/消化道肿瘤Key words
autophagy/drug resistance/gastrointestinal tumors分类
医药卫生引用本文复制引用
吴锦玉,刘叶荣,罗宏涛,白彪胜,张金花..靶向自噬调控消化道肿瘤化疗耐药性的研究进展[J].解放军医学杂志,2026,51(4):522-530,9.基金项目
This work was supported by the Natural Science Foundation of Gansu Province(25JRRA265) 甘肃省自然科学基金(25JRRA265) （25JRRA265）
