实用临床医药杂志2026，Vol.30Issue(7)：14-18,5.DOI:10.7619/jcmp.20256654
血清神经元PAS结构域蛋白4、膜联蛋白A2、血小板内皮细胞黏附分子-1水平与急性脑梗死患者静脉溶栓预后的关系
Relationship between serum levels of neuronal PAS domain protein 4,Annexin A2,platelet endothelial cell adhesion molecule-1 and prognosis of intravenous thrombolysis in patients with acute cerebral infarction
摘要
Abstract
Objective To investigate the relationship between neuronal PAS domain protein 4(NPASDP4),Annexin A2,platelet endothelial cell adhesion molecule-1(PECAM-1)and the prog-nosis of intravenous thrombolysis in patients with acute cerebral infarction(ACI).Methods A total of 117 ACI patients who received thrombolytic therapy were selected as ACI group,and 100 healthy individuals who underwent physical examinations during the same period were selected as control group.The serum levels of NPASDP4,Annexin A2,and PECAM-1 in the two groups were com-pared.According to the modified Rankin Scale(mRS)score 3 months after thrombolytic therapy,ACI patients were divided into poor prognosis group(n=38,3 to 6 points)and good prognosis group(n=79,0 to 2 points).The clinical data of the two groups were compared.Multivariate Logistic regression analysis was used to screen the influencing factors for poor prognosis in ACI pa-tients.The predictive value of single and combined indicators for prognosis was evaluated by the re-ceiver operating characteristic(ROC)curve.Results The serum levels of NPASDP4,Annexin A2,and PECAM-1 in the ACI group were higher than those in the control group,and the differences were statistically significant(P＜0.05).The National Institutes of Health Stroke Scale(NIHSS)score at admission and the serum levels of NPASDP4,Annexin A2,and PECAM-1 in the poor prog-nosis group were higher than those in the good prognosis group,and the differences were statistically significant(P＜0.05).Multivariate Logistic regression analysis showed that an increased NIHSS score at admission and elevated serum levels of NPASDP4,Annexin A2,and PECAM-1 were inde-pendent risk factors for poor prognosis in ACI patients(P＜0.05).ROC curve analysis showed that the area under the curve for the combined prediction of prognosis in ACI patients by serum NPASDP4,Annexin A2,and PECAM-1 was 0.900,with a sensitivity of 89.47％and a specificity of 88.61％,which was superior to the predictive efficacy of each indicator alone(P＜0.05).Conclusion The serum levels of Annexin A2,NPASDP4,and PECAM-1 in ACI patients are significantly increased,and the levels in patients with poor prognosis are higher than those in patients with good prognosis.Elevated serum levels of NPASDP4,Annexin A2,and PECAM-1 are risk factors for poor prognosis of intravenous thrombolysis in ACI patients,and the combined detection of the three indicators has a high predictive value for prognosis.关键词
急性脑梗死/静脉溶栓/预后/神经元PAS结构域蛋白4/膜联蛋白A2/血小板内皮细胞黏附分子-1/生物标志物/多因素Logistic回归分析Key words
acute cerebral infarction/intravenous thrombolysis/prognosis/neuronal PAS do-main protein 4/Annexin A2/platelet endothelial cell adhesion molecule-1/biomarkers/multivari-ate Logistic regression analysis分类
医药卫生引用本文复制引用
王浩然,郝智军,李景莉,周娜..血清神经元PAS结构域蛋白4、膜联蛋白A2、血小板内皮细胞黏附分子-1水平与急性脑梗死患者静脉溶栓预后的关系[J].实用临床医药杂志,2026,30(7):14-18,5.基金项目
国家自然科学基金项目(8211035231) （8211035231）
湖南省卫生健康委科研计划项目(C202302088588) （C202302088588）
