实用临床医药杂志2026，Vol.30Issue(7)：19-26,8.DOI:10.7619/jcmp.20256099
高强度间歇训练理念有氧舞蹈对老年轻度认知障碍执行功能的影响及机制
Effects of aerobic dance based on high-intensity interval training concept on executive function in elderly patients with mild cognitive impairment and its mechanisms
摘要
Abstract
Objective To observe the improvement effect of aerobic dance based on the high-in-tensity interval training(HIIT)concept on cognitive executive function in elderly patients with mild cogni-tive impairment(MCI)and explore its underlying mechanisms from the perspective of"excitotoxicity-oxi-dative stress"by comparing the changes in plasma glutamate,arginine,and malondialdehyde(MDA)lev-els before and after intervention.Methods This was a multi-center,prospective,randomized,controlled clinical trial.Elderly patients with MCI recruited jointly by the Department of Rehabilitation Medicine of the Northern Jiangsu People's Hospital of Jiangsu Province and the Department of Encephalopathy of the Yangzhou Traditional Chinese Medicine Hospital from March 2021 to March 2022 were includ-ed as the study subjects.After 3 months of intervention,45 subjects were finally included in this study,with 23 in the exercise group and 22 in the control group.The exercise group received aero-bic dance intervention based on the HIIT concept for 3 months,while the control group only received relevant health education.Results After intervention,the Montreal Cognitive Assessment(MoCA)score,Digital Span Test(DST),Trail Making Test Part B(TMT-B),Stroop Color-Word Test In-terference Effect(SIE)time-consuming,maximal oxygen uptake(VO2max),and plasma arginine,glutamate,and MDA levels in the exercise group showed significant improvements compared with those before intervention(P＜0.05).After intervention,The DST score,TMT-B,SIE score,VO2max,and plasma glutamate and MDA levels in the exercise group were superior to those in the control group,with statistically significant differences(P＜0.05).Conclusion Aerobic dance in-tervention designed based on the HIIT concept can significantly improve executive function in elderly patients with MCI.Its underlying mechanisms may be related to the reduction in plasma glutamate and arginine levels and the alleviation of brain oxidative stress injury.The"excitotoxicity-oxidative stress"regulatory metabolic pathway provides a new perspective for understanding the neurobiologi-cal mechanisms of exercise benefits for the brain and subsequent related biomarker research.关键词
轻度认知障碍/执行功能/高强度间歇训练/舞蹈疗法/氧化应激/谷氨酸/精氨酸/随机对照试验Key words
mild cognitive impairment/executive function/high-intensity interval training/dance therapy/oxidative stress/glutamate/arginine/randomized controlled trial分类
医药卫生引用本文复制引用
周洪雨,刘彦廷,全逸峰,吕艺宸,李冰一,王鑫,王建建,汤佳,胡曼嫣,张燕..高强度间歇训练理念有氧舞蹈对老年轻度认知障碍执行功能的影响及机制[J].实用临床医药杂志,2026,30(7):19-26,8.基金项目
国家自然科学基金面上项目(82072533) （82072533）
扬州市科技计划项目(YZ2024107) （YZ2024107）
扬州市科技计划项目(YZ2023088) （YZ2023088）
江苏省哲学社会科学基金项目(22SHD005) （22SHD005）
扬州市卫生健康委员会科研项目(2023-2-09) （2023-2-09）
扬州市基础研究计划卫生健康类项目(2024-2-15) （2024-2-15）
扬州市科技局政策引导类计划(国际科技合作项目)(YZ2022203) （国际科技合作项目）
