实用临床医药杂志2026，Vol.30Issue(7)：54-59,66,7.DOI:10.7619/jcmp.20254034
血糖特征与路易体痴呆的因果关联:孟德尔随机化研究
Glycemic traits and dementia with Lewy body:Mendelian randomization study
摘要
Abstract
Objective To systematically evaluate the potential causal relationship between gly-caemic traits and the risk of dementia with Lewy bodies(DLB)from a genetic epidemiological per-spective using the Mendelian randomization(MR)method.Methods Based on publicly available genome-wide association study(GWAS)data,fasting glucose,glycated hemoglobin(HbA1c),fast-ing insulin,and type 2 diabetes were selected as exposure variables,and DLB as the outcome varia-ble.The inverse variance weighted(IVW)method was employed to infer the potential causal rela-tionship between glycaemic traits and DLB risk,supplemented by MR-Egger regression and MR-PRESSO analysis to detect horizontal pleiotropy and heterogeneity.Cochran's Q test was used to assess heterogeneity,and leave-one-outanalysis was conducted to verify the robustness of the results.Results IVW analysis indicated that both fasting glucose(OR=2.47,95％CI,1.14 to 5.38,P=0.02)and HbA1c levels(OR=1.31,95％CI,1.02 to 1.62,P=0.03)were positively causally associated with an increased risk of DLB.No significant associations were observed between genetic variants related to fasting insulin,type 2 diabetes and the risk of DLB.The sensitivity analysis results were consistent,and reverse MR analysis did not reveal significant reverse causal effects of DLB on gly-caemic indices.Conclusion This study provides genetic epidemiological evidence that hyperglycemic states increase the risk of DLB,suggesting that glycaemic control may be of great significance in the prevention strategies for DLB.关键词
血糖代谢/路易体痴呆/糖化血红蛋白/孟德尔随机化/空腹血糖/因果关系/遗传流行病学/神经退行性疾病Key words
glycemic metabolism/Lewy body dementia/glycated hemoglobin/Mendelian ran-domization/fasting blood glucose/causal inference/genetic epidemiology/neurodegenerative diseases分类
医药卫生引用本文复制引用
刘于宁,张银洋,岳冉,李欣宇,崔桂云,徐传英..血糖特征与路易体痴呆的因果关联:孟德尔随机化研究[J].实用临床医药杂志,2026,30(7):54-59,66,7.基金项目
国家自然科学基金项目(82401683) （82401683）
江苏省高水平建设项目(GSPJS202424) （GSPJS202424）
