军事医学2026，Vol.50Issue(4)：310-315,6.DOI:10.7644/j.issn.1674-9960.2025-00220
时钟基因BMAL1调节肌耐力的研究进展
Research progress in roles of clock gene BMAL1 in regulating muscle endurance
摘要
Abstract
Flight fatigue can impact the ability of pilots to complete long endurance cross-domain flight missions,and skeletal muscle fatigue caused by insufficient muscle endurance is an important cause of flight fatigue.Circadian rhythm and clock genes reportedly play an important role in regulating muscle endurance,and BMAL1 is one of the core clock genes that affect muscle endurance by regulating muscle metabolism,energy production,and muscle fiber-type switching.Disturbance of circadian rhythm or abnormal expressions of BMAL1 can lead to decreased muscle endurance,resulting in body fatigue.In this paper,the research progress in the role of clock gene BMAL1 in regulating muscle endurance is reviewed,which is expected to provide insights and methods for improving muscle endurance and anti-fatigue ability of pilots in long-endurance cross-domain flights.关键词
飞行疲劳/BMAL1/昼夜节律/肌耐力Key words
flight fatigue/BMAL1/circadian rhythm/muscle endurance分类
社会科学引用本文复制引用
杨皓,仁青扎西,王瑞,梁雅楠,柴锐青,张沛然,张同梅,赵星成..时钟基因BMAL1调节肌耐力的研究进展[J].军事医学,2026,50(4):310-315,6.基金项目
国家自然科学基金(82304019) （82304019）
