检验医学与临床2026，Vol.23Issue(9)：1159-1164,6.DOI:10.3969/j.issn.1672-9455.2026.09.002
血清JKAP和CDC42对糖尿病肾病患者预后不良的预测价值
Predictive value of serum JKAP and CDC42 for poor prognosis in patients with diabetic nephropathy
摘要
Abstract
Objective To analyze the predictive value of serum Jun N-terminal kinase pathway-related phosphatase(JKAP)and cell division cycle protein 42(CDC42)for poor prognosis in patients with diabetic nephropathy(DN).Methods A total of 186 patients with DN admitted to Sichuan University West China Hospital Mianzhu Hospital from February 2019 to February 2021 were selected as the study group.Another 60 patients with simple type 2 diabetes mellitus(T2DM)without DN who were diagnosed and treated in the Sichuan University West China Hospital Mianzhu Hospital at the same period were selected as the disease control group,and 60 healthy individuals who underwent physical examination in the Sichuan University West China Hospital Mianzhu Hospital at the same period were selected as the control group.Follow-up for 3 years.DN patients were divided into good prognosis group and poor prognosis group according to the progno-sis.Serum JKAP and CDC42 levels were detected by enzyme-linked immunosorbent assay.Multivariate Logis-tic regression analysis was used to analyze the influencing factors of poor prognosis in DN patients.Receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of serum JKAP and CDC42 for poor prognosis in DN patients.Results The serum JKAP and CDC42 levels in the disease control group and the study group were lower than those in the control group,and those in the study group were lower than those in the disease control group,and the differences were statistically significant(P＜0.05).The 24 h urine protein quantification and serum creatinine level in the poor prognosis group were higher than those in the good prognosis group,the glomerular filtration rate(eGFR)and serum JKAP and CDC42 levels were lower than those in the good prognosis group,and the glomerular pathological grade was higher than that in the good prognosis group,and the differences were all statistically significant(P＜0.05).Multivariate Logistic regres-sion analysis results showed that elevated serum creatinine level,24 h urine protein quantification level and glomerular pathological grade Ⅲ or Ⅳ were risk factors for poor prognosis in DN patients(P＜0.05),and el-evated eGFR and serum JKAP,CDC42 levels were protective factors for poor prognosis in DN patients(P＜0.05).ROC curve analysis results showed that the area under the curve(AUC)of serum JKAP,CDC42 alone and the combination of the two indicators for predicting poor prognosis in DN patients were 0.848,0.844 and 0.905 respectively.The AUC of the combination of the two indicators was greater than that of serum JKAP and CDC42 alone(Z=4.130,4.040,both P＜0.05).Conclusion The serum JKAP and CDC42 levels of DN patients are decreased,and two indicators can be used as serum markers for predicting poor prognosis in DN patients.关键词
糖尿病肾病/Jun N-末端激酶通路相关磷酸酶/细胞分裂周期蛋白42/预后/预测Key words
diabetic nephropathy/Jun N-terminal kinase pathway-related phosphatase/cell division cycle protein 42/prognosis/prediction分类
医药卫生引用本文复制引用
杨亮,陈长云,骆强..血清JKAP和CDC42对糖尿病肾病患者预后不良的预测价值[J].检验医学与临床,2026,23(9):1159-1164,6.基金项目
四川省中医药管理局科学技术研究专项(2021MS086). （2021MS086）
