检验医学与临床2026，Vol.23Issue(9)：1183-1189,7.DOI:10.3969/j.issn.1672-9455.2026.09.006
血清UCP2、脑组织净水摄取率、入院时NIHSS评分、ASPECTS评分对急性大血管闭塞性脑卒中机械取栓术后发生恶性脑水肿的预测价值
The predictive value of serum UCP2,brain tissue clean water uptake rate,NIHSS score at admission and ASPECTS score for malignant cerebral edema in patients with acute large vessel occlusive stroke after mechanical thrombectomy
摘要
Abstract
Objective To investigate the predictive value of serum uncoupling protein 2(UCP2)combined with brain tissue water uptake rate(NWU),National Institutes of Health Stroke Scale(NIHSS)score at ad-mission,Alberta Stroke Program Early CT(ASPECTS)score for malignant cerebral edema(MCE)in pa-tients with acute large vessel occlusive stroke(ASI-LVO)after mechanical thrombectomy.Methods A total of 300 patients with AIS-LVO who underwent mechanical thrombectomy in the hospital from May 2022 to January 2025 were selected as the research objects.According to the occurrence of postoperative MCE,the pa-tients were divided into MCE group and non-MCE group.The serum UCP2 levels of all patients were detected before operation,and the brain CT examination was performed to obtain NWU.Multivariate Logistic regres-sion was used to analyze the related factors of MCE after mechanical thrombectomy in patients with AIS-LVO.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of NIHSS score at admission,ASPECTS score,NWU and serum UCP2 for MCE in patients with ASI-LVO after me-chanical thrombectomy.Results The serum UCP2 level in the MCE group was lower than that in the non-MCE group,and the NWU was higher than that in the non-MCE group,and the differences were statistically significant(P＜0.05).The age and infarct size of the MCE group were larger than those of the non-MCE group,the NIHSS score at admission was higher than that of the non-MCE group,and the postoperative AS-PECTS score was lower than that of the non-MCE group,and the differences were statistically significant(P＜0.05).Multivariate Logistic regression analysis showed that NIHSS score at admission,NWU,serum UCP2 and ASPECTS score were related factors of MCE after mechanical thrombectomy in patients with ASI-LVO(P＜0.05).The results of ROC curve analysis showed that the area under the curve(AUC)of the com-bination of 4 indicators for predicting MCE after mechanical thrombectomy in patients with AIS-LVO was 0.943,which was larger than the AUC predicted by NIHSS score at admission,ASPECTS score,UCP2 and NWU alone(Z=5.225,5.043,4.276,4.892;all P＜0.05).Conclusion NWU,NIHSS score at admission,ASPECTS score and serum UCP2 are related to the occurrence of MCE in patients with ASI-LVO after me-chanical thrombectomy.The combination of the 4 indicators has a high efficacy in predicting the risk of MCE.关键词
急性大血管闭塞性脑卒中/机械取栓术/恶性脑水肿/解偶联蛋白2/脑组织净水摄取率Key words
acute large vessel occlusion stroke/mechanical thrombectomy/malignant brain edema/uncoupling protein 2/brain tissue clean water uptake rate分类
医药卫生引用本文复制引用
李巍,李书成,刘柯婷..血清UCP2、脑组织净水摄取率、入院时NIHSS评分、ASPECTS评分对急性大血管闭塞性脑卒中机械取栓术后发生恶性脑水肿的预测价值[J].检验医学与临床,2026,23(9):1183-1189,7.基金项目
四川省卫生健康委员会科研课题项目(20PJ219). （20PJ219）
