检验医学与临床2026，Vol.23Issue(10)：1313-1319,7.DOI:10.3969/j.issn.1672-9455.2026.10.003
冠心病患者PCI术前血清CgA、GDF11、FDX1水平与术后MACE的关系
Relationship between serum CgA,GDF11 and FDX1 levels before PCI and postoperative major adverse cardiovascular events in patients with coronary heart disease
摘要
Abstract
Objective To explore the relationship between preoperative serum chromogranin A(CgA),growth differentiation factor 11(GDF11)and ferredoxin 1(FDX1)levels with postoperative major adverse cardiovascular events(MACE)in the patients with coronary heart disease(CHD)undergoing percutaneous coronary intervention(PCI).Methods A total of 153 patients with CHD admitted and treated in this hospital from October 2021 to October 2023 were selected as the research subjects.The patients were followed up for 6 months after PCI.Based on the occurrence of MACE during the follow-up period,the patients were divided in-to the MACE group and non-MACE group.Serum CgA,GDF11 and FDX1 levels were detected by the en-zyme-linked immunosorbent assay(ELISA).The multivariate Logistic regression was used to analyze the in-fluencing factors of MACE occurrence after PCI in CHD patients.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive efficiency of serum CgA,GDF11 and FDX1 alone and 3-item combi-nation for the MACE occurrence after PCI in CHD patients.Results Compared with the non-MACE group,the proportion of New York Heart Association(NYHA)function class Ⅱ-Ⅲ,proportion of multivessel dis-ease and serum CgA level in the MACE group were higher,while the serum GDF11 and FDX1 levels were lower,and the differences were statistically significant(P<0.05).The multivariate Logistic regression analy-sis showed that increased serum CgA level,NYHA function class Ⅱ-Ⅲ,and multivessel disease were all risk factors for MACE after PCI in CHD patients(P<0.05);increased serum GDF11 and FDX1 levels were both protective factors for MACE after PCI in CHD patients(P<0.05).The areas under the curves(AUCs)of se-rum CgA,GDF11 and FDX1 alone and 3-item combination for predicting the MACE occurrence after PCI in CHD patients were 0.863,0.872,0.757 and 0.962,respectively.The AUC of the 3-item combination was greater than that of serum CgA(Z=3.619,P<0.001),GDF11(Z=3.209,P=0.001),and FDX1(Z=4.978,P<0.001)alone.Conclusion The serum CgA level before PCI is increased in CHD patients with post-operative MACE occurrence,while the serum GDF11 and FDX1 levels are decreased.The combined detection of the serum CgA,GDF11 and FDX1 has a higher predictive value for MACE after PCI,which could provide a reference for the early screening of high-risk populations in clinic.关键词
冠心病/嗜铬粒蛋白A/生长分化因子11/铁氧还蛋白1/主要不良心血管事件/经皮冠状动脉介入治疗Key words
coronary heart disease/chromogranin A/growth differentiation factor 11/ferredoxin-1/major adverse cardiovascular events/percutaneous coronary intervention分类
医药卫生引用本文复制引用
严昕,郑宏超,缪培智..冠心病患者PCI术前血清CgA、GDF11、FDX1水平与术后MACE的关系[J].检验医学与临床,2026,23(10):1313-1319,7.基金项目
上海市徐汇区卫生健康委员会项目(SHXHZDXK202305). （SHXHZDXK202305）
